Rat behavior and dopamine release are modulated by conspecific distress
Date
2018Journal
eLifePublisher
eLife Sciences Publications LtdType
Article
Metadata
Show full item recordAbstract
Rats exhibit "empathy" making them a model to understand the neural underpinnings of such behavior. We show data consistent with these findings, but also that behavior and dopamine (DA) release reflects subjective rather than objective evaluation of appetitive and aversive events that occur to another. We recorded DA release in two paradigms: one that involved cues predictive of unavoidable shock to the conspecific and another that allowed the rat to refrain from reward when there were harmful consequences to the conspecific. Behavior and DA reflected pro-social interactions in that DA suppression was reduced during cues that predicted shock in the presence of the conspecific and that DA release observed on self-avoidance trials was present when the conspecific was spared. However, DA also increased when the conspecific was shocked instead of the recording rat and DA release during conspecific avoidance trials was lower than when the rat avoided shock for itself. Copyright Lichtenberg et al.Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057232027&doi=10.7554%2feLife.38090&partnerID=40&md5=b88d7557b29a2aab63153deac3df8d28; http://hdl.handle.net/10713/9699ae974a485f413a2113503eed53cd6c53
10.7554/eLife.38090
Scopus Count
Collections
Related articles
- Observation of reward delivery to a conspecific modulates dopamine release in ventral striatum.
- Authors: Kashtelyan V, Lichtenberg NT, Chen ML, Cheer JF, Roesch MR
- Issue date: 2014 Nov 3
- Anterior Cingulate Cortex Signals Attention in a Social Paradigm that Manipulates Reward and Shock.
- Authors: Schneider KN, Sciarillo XA, Nudelman JL, Cheer JF, Roesch MR
- Issue date: 2020 Oct 5
- Dopamine in the nucleus accumbens core, but not shell, increases during signaled food reward and decreases during delayed extinction.
- Authors: Biesdorf C, Wang AL, Topic B, Petri D, Milani H, Huston JP, de Souza Silva MA
- Issue date: 2015 Sep
- The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking.
- Authors: Ikemoto S, Panksepp J
- Issue date: 1999 Dec
- Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance.
- Authors: Gentry RN, Lee B, Roesch MR
- Issue date: 2016 Oct 27