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dc.contributor.authorAdebamowo, S.N.
dc.contributor.authorFrancis, V.
dc.contributor.authorTambo, E.
dc.date.accessioned2019-06-21T18:46:26Z
dc.date.available2019-06-21T18:46:26Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053390875&doi=10.1080%2f16549716.2017.1419033&partnerID=40&md5=98e771acb38ed89f660751e77690ea1d
dc.identifier.urihttp://hdl.handle.net/10713/9694
dc.description.abstractBackground: There is exponential growth in the interest and implementation of genomics research in Africa. This growth has been facilitated by the Human Hereditary and Health in Africa (H3Africa) initiative, which aims to promote a contemporary research approach to the study of genomics and environmental determinants of common diseases in African populations. Objective: The purpose of this article is to describe important challenges affecting genomics research implementation in Africa. Methods: The observations, challenges and recommendations presented in this article were obtained through discussions by African scientists at teleconferences and face-to-face meetings, seminars at consortium conferences and in-depth individual discussions. Results: Challenges affecting genomics research implementation in Africa, which are related to limited resources include ill-equipped facilities, poor accessibility to research centers, lack of expertise and an enabling environment for research activities in local hospitals. Challenges related to the research study include delayed funding, extensive procedures and interventions requiring multiple visits, delays setting up research teams and insufficient staff training, language barriers and an underappreciation of cultural norms. While many African countries are struggling to initiate genomics projects, others have set up genomics research facilities that meet international standards. Conclusions: The lessons learned in implementing successful genomics projects in Africa are recommended as strategies to overcome these challenges. These recommendations may guide the development and application of new research programs in low-resource settings. Copyright 2018, Copyright 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.description.sponsorshipThis work was supported by the following grants from the National Institutes of Health U54HG006938, 1U54HG006947, U01HG009784, 1U01HG007654, 1U01HG007046, UH2HG007008, UH3HG007008, U01HG007044 and the following grants from the Wellcome Trust 099313/Z/12/Z, 099310/Z/12/A.en_US
dc.description.urihttps://dx.doi.org/10.1080/16549716.2017.1419033en_US
dc.language.isoen-USen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofGlobal Health Action
dc.subjectAfricaen_US
dc.subjectchallengesen_US
dc.subjectgenomicsen_US
dc.subjectH3Africaen_US
dc.subjectresearch implementationen_US
dc.titleImplementation of genomics research in Africa: challenges and recommendationsen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/16549716.2017.1419033
dc.identifier.pmid29336236


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