Implementation of genomics research in Africa: challenges and recommendations
JournalGlobal Health Action
PublisherTaylor and Francis Ltd.
MetadataShow full item record
AbstractBackground: There is exponential growth in the interest and implementation of genomics research in Africa. This growth has been facilitated by the Human Hereditary and Health in Africa (H3Africa) initiative, which aims to promote a contemporary research approach to the study of genomics and environmental determinants of common diseases in African populations. Objective: The purpose of this article is to describe important challenges affecting genomics research implementation in Africa. Methods: The observations, challenges and recommendations presented in this article were obtained through discussions by African scientists at teleconferences and face-to-face meetings, seminars at consortium conferences and in-depth individual discussions. Results: Challenges affecting genomics research implementation in Africa, which are related to limited resources include ill-equipped facilities, poor accessibility to research centers, lack of expertise and an enabling environment for research activities in local hospitals. Challenges related to the research study include delayed funding, extensive procedures and interventions requiring multiple visits, delays setting up research teams and insufficient staff training, language barriers and an underappreciation of cultural norms. While many African countries are struggling to initiate genomics projects, others have set up genomics research facilities that meet international standards. Conclusions: The lessons learned in implementing successful genomics projects in Africa are recommended as strategies to overcome these challenges. These recommendations may guide the development and application of new research programs in low-resource settings. Copyright 2018, Copyright 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
SponsorsThis work was supported by the following grants from the National Institutes of Health U54HG006938, 1U54HG006947, U01HG009784, 1U01HG007654, 1U01HG007046, UH2HG007008, UH3HG007008, U01HG007044 and the following grants from the Wellcome Trust 099313/Z/12/Z, 099310/Z/12/A.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053390875&doi=10.1080%2f16549716.2017.1419033&partnerID=40&md5=98e771acb38ed89f660751e77690ea1d; http://hdl.handle.net/10713/9694
- Genomics and bioinformatics capacity in Africa: no continent is left behind.
- Authors: Mboowa G, Sserwadda I, Aruhomukama D
- Issue date: 2021 May
- Development of Bioinformatics Infrastructure for Genomics Research.
- Authors: Mulder NJ, Adebiyi E, Adebiyi M, Adeyemi S, Ahmed A, Ahmed R, Akanle B, Alibi M, Armstrong DL, Aron S, Ashano E, Baichoo S, Benkahla A, Brown DK, Chimusa ER, Fadlelmola FM, Falola D, Fatumo S, Ghedira K, Ghouila A, Hazelhurst S, Isewon I, Jung S, Kassim SK, Kayondo JK, Mbiyavanga M, Meintjes A, Mohammed S, Mosaku A, Moussa A, Muhammd M, Mungloo-Dilmohamud Z, Nashiru O, Odia T, Okafor A, Oladipo O, Osamor V, Oyelade J, Sadki K, Salifu SP, Soyemi J, Panji S, Radouani F, Souiai O, Tastan Bishop Ö, H3ABioNet Consortium, as members of the H3Africa Consortium.
- Issue date: 2017 Jun
- Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop.
- Authors: Joubert BR, Berhane K, Chevrier J, Collman G, Eskenazi B, Fobil J, Hoyo C, John CC, Kumie A, Nicol M, Ramsay M, Smith J, Steyn A, Tshala-Katumbay D, McAllister K
- Issue date: 2019
- Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics.
- Authors: Baichoo S, Souilmi Y, Panji S, Botha G, Meintjes A, Hazelhurst S, Bendou H, Beste E, Mpangase PT, Souiai O, Alghali M, Yi L, O'Connor BD, Crusoe M, Armstrong D, Aron S, Joubert F, Ahmed AE, Mbiyavanga M, Heusden PV, Magosi LE, Zermeno J, Mainzer LS, Fadlelmola FM, Jongeneel CV, Mulder N
- Issue date: 2018 Nov 29
- H3Africa and the African life sciences ecosystem: building sustainable innovation.
- Authors: Dandara C, Huzair F, Borda-Rodriguez A, Chirikure S, Okpechi I, Warnich L, Masimirembwa C
- Issue date: 2014 Dec