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dc.contributor.authorConnolly, N.P.
dc.contributor.authorShetty, A.C.
dc.contributor.authorStokum, J.A.
dc.date.accessioned2019-06-21T18:46:24Z
dc.date.available2019-06-21T18:46:24Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85040825594&doi=10.1038%2fs41598-018-19451-6&partnerID=40&md5=dbebe5370d29f1f6e177fd8b72643048
dc.identifier.urihttp://hdl.handle.net/10713/9670
dc.description.abstractGlioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis and tumor progression. We investigated the differences and similarities in glioma biology as conveyed by transcriptomic patterns across four mammalian hosts: rats, mice, dogs, and humans. Given the inherent intra-tumoral molecular heterogeneity of human glioma, we focused this study on tumors with upregulation of the platelet-derived growth factor signaling axis, a common and early alteration in human gliomagenesis. The results reveal core neoplastic alterations in mammalian glioma, as well as unique contributions of the tumor host to neoplastic processes. Notable differences were observed in gene expression patterns as well as related biological pathways and cell populations known to mediate key elements of glioma biology, including angiogenesis, immune evasion, and brain invasion. These data provide new insights regarding mammalian models of human glioma, and how these insights and models relate to our current understanding of the human disease. Copyright 2018 The Author(s).en_US
dc.description.sponsorshipThis study was supported by NIH T32 CA154274 (NC), NIH F30-CA200345-01 (MBS), NIH R01CA139099 (JHR); the Wallace Coulter Foundation (JHR); the Passano Foundation (GW); NIH K12 NS080223 Neurosurgeon Research Career Development Program (GW), NIH K08 NS090430 (GW), American Cancer Society-Research Scholar Grant 128970-RSG-16-012-01-CDD (GW).en_US
dc.description.urihttps://dx.doi.org/10.1038/s41598-018-19451-6en_US
dc.language.isoen-USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGliomaen_US
dc.titleCross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian gliomaen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-018-19451-6
dc.identifier.pmid29352201


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