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dc.contributor.authorHarris, M.L.
dc.contributor.authorFufa, T.D.
dc.contributor.authorPalmer, J.W.
dc.date.accessioned2019-06-21T18:46:23Z
dc.date.available2019-06-21T18:46:23Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85047950161&doi=10.1371%2fjournal.pbio.2003648&partnerID=40&md5=fa89b8c6fb071260dcc9c86ac5bf9c98
dc.identifier.urihttp://hdl.handle.net/10713/9650
dc.description.abstractMelanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the maintenance of regenerating tissues. Interested in assessing genetic variants that influence McSC maintenance, we found previously that heterozygosity for the melanogenesis associated transcription factor, Mitf, exacerbates McSC differentiation and hair graying in mice that are predisposed for this phenotype. Based on transcriptome and molecular analyses of Mitf mi-vga9/+ mice, we report a novel role for MITF in the regulation of systemic innate immune gene expression. We also demonstrate that the viral mimic poly(I:C) is sufficient to expose genetic susceptibility to hair graying. These observations point to a critical suppressor of innate immunity, the consequences of innate immune dysregulation on pigmentation, both of which may have implications in the autoimmune, depigmenting disease, vitiligo. Copyright 2018 Public Library of Science. All Rights Reserved. https://creativecommons.org/publicdomain/zero/1.0/en_US
dc.description.urihttps://dx.doi.org/10.1371/journal.pbio.2003648en_US
dc.language.isoen-USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS Biology
dc.subjectmelanocyte stem cellsen_US
dc.subject.meshImmunity, Innateen_US
dc.subject.meshMicrophthalmia-Associated Transcription Factoren_US
dc.subject.meshPigmentation--immunologyen_US
dc.titleA direct link between MITF, innate immunity, and hair grayingen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pbio.2003648


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