Date
2018Journal
PLoS BiologyPublisher
Public Library of ScienceType
Article
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Melanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the maintenance of regenerating tissues. Interested in assessing genetic variants that influence McSC maintenance, we found previously that heterozygosity for the melanogenesis associated transcription factor, Mitf, exacerbates McSC differentiation and hair graying in mice that are predisposed for this phenotype. Based on transcriptome and molecular analyses of Mitf mi-vga9/+ mice, we report a novel role for MITF in the regulation of systemic innate immune gene expression. We also demonstrate that the viral mimic poly(I:C) is sufficient to expose genetic susceptibility to hair graying. These observations point to a critical suppressor of innate immunity, the consequences of innate immune dysregulation on pigmentation, both of which may have implications in the autoimmune, depigmenting disease, vitiligo. Copyright 2018 Public Library of Science. All Rights Reserved. https://creativecommons.org/publicdomain/zero/1.0/Keyword
melanocyte stem cellsImmunity, Innate
Microphthalmia-Associated Transcription Factor
Pigmentation--immunology
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047950161&doi=10.1371%2fjournal.pbio.2003648&partnerID=40&md5=fa89b8c6fb071260dcc9c86ac5bf9c98; http://hdl.handle.net/10713/9650ae974a485f413a2113503eed53cd6c53
10.1371/journal.pbio.2003648