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    Characterization of invasive salmonella serogroup c1 infections in Mali

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    Author
    Fuche, F.J.
    Sen, S.
    Jones, J.A.
    Date
    2018
    Journal
    American Journal of Tropical Medicine and Hygiene
    Publisher
    American Society of Tropical Medicine and Hygiene
    Type
    Article
    
    Metadata
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    See at
    https://dx.doi.org/10.4269/ajtmh.17-0508
    Abstract
    Nontyphoidal Salmonella (NTS) are the leading cause of foodborne infections worldwide and a major cause of bloodstream infections in infants and HIV-infected adults in sub-Saharan Africa (SSA). Salmonella Typhimurium (serogroup B) and Salmonella Enteritidis (serogroup D) are the most common serovars in this region. However, data describing rarer invasive NTS serovars, particularly those belonging to serogroups C1 and C2, circulating in SSA are lacking. We previously conducted systematic blood culture surveillance on pediatric patients in Bamako, Mali, from 2002 to 2014, and the results showed that serovars Typhimurium and Enteritidis accounted for 32% and 36% of isolates, respectively. Here, we present data on 27 Salmonella serogroup C1 strains that were isolated during this previous study. The strains were typed by serum agglutination and multilocus sequence typing (MLST). Sixteen strains were Salmonella Paratyphi C, four were Salmonella Colindale, and two were Salmonella Virchow. Interestingly, five strains were identified as the very rare Salmonella Brazzaville using a combination of serum agglutination and flagellin gene typing. Phenotypic characterization showed that Salmonella Brazzaville produced biofilm and exhibited catalase activity, which were not statistically different from the gastroenteritis-associated Salmonella Typhimurium sequence type (ST) 19. All tested Salmonella Paratyphi C strains were poor biofilm producers and showed significantly less catalase activity than Salmonella Typhimurium ST19. Overall, our study provides insight into the Salmonella serogroup C1 serovars that cause invasive disease in infants in Mali. In addition, we show that MLST and flagellin gene sequencing, in association with traditional serum agglutination, are invaluable tools to help identify rare Salmonella serovars. Copyright Copyright 2018 by The American Society of Tropical Medicine and Hygiene.
    Sponsors
    This work was funded by Project 4: Vaccine strategy for broad spectrum protection against nontyphoidal Salmonella (project leaders: Sharon M. Tennant and Raphael Simon) NIH/NIAID Centers for Excellence in Translation Research grant U19 AI109776-01 awarded to Myron M. Levine.
    Keyword
    nontyphoidal Salmonella
    Salmonella--genetics
    Salmonella Infections
    Serogroup
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041523596&doi=10.4269%2fajtmh.17-0508&partnerID=40&md5=4525c3354dd676fe33e55dd036e25caa; http://hdl.handle.net/10713/9642
    ae974a485f413a2113503eed53cd6c53
    10.4269/ajtmh.17-0508
    Scopus Count
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    UMB Open Access Articles 2018

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