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    Evaluation of a Poly(Lactic-Co-Glycolic) Acid-Coated β-Tricalcium Phosphate Bone Substitute for Alveolar Ridge Preservation: Multicenter Randomized Control Trial

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    Author
    West, Brandon M.
    Advisor
    Saito, Hanae
    Date
    2019
    Type
    dissertation
    
    Metadata
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    Abstract
    Purpose: The aim of this study was to determine whether the efficacy of PLGA-β-TCP in Alveolar Ridge Preservation (ARP) with histological analysis of the extraction socket following four months healing was similar to FDBA + CP as the control. Materials and Methods: 45 adult patients in this multicenter randomized controlled clinical trial were randomly assigned into treatment group A [PLGA-β-TCP] or group B [FDBA + CP] for ARP of a single extraction socket. Results: 45 bone core samples were harvested. Vital bone was present in intimate contact with the surface of β-TCP graft particles. Histologic measurements revealed no statistically significant difference between the test and control groups in percent vital bone after four months healing. Conclusion: This investigation demonstrated the similar efficacy of PLGA- β-TCP to FDBA as a bone substitute in ARP.
    Description
    2019
    Biomedical Sciences-Dental School
    University of Maryland , Baltimore
    M.S.
    Keyword
    alveolar ridge preservation
    PLGA
    β-TCP
    beta tricalcium phosphate
    Bone Substitutes
    Polylactic Acid-Polyglycolic Acid Copolymer
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/9579
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    Theses and Dissertations School of Dentistry
    Theses and Dissertations All Schools

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