Author
Proctor, Lita M.Creasy, Heather H.
White, Owen
Huttenhower, Curtis
The Integrative HMP (iHMP) Research Network Consortium
Date
2019-05-30Journal
NaturePublisher
Nature Publishing GroupType
Article
Metadata
Show full item recordAbstract
The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions between humans and their microbiomes to health-related outcomes. The recently completed second phase, the Integrative Human Microbiome Project, comprised studies of dynamic changes in the microbiome and host under three conditions: pregnancy and preterm birth; inflammatory bowel diseases; and stressors that affect individuals with prediabetes. The associated research begins to elucidate mechanisms of host–microbiome interactions under these conditions, provides unique data resources (at the HMP Data Coordination Center), and represents a paradigm for future multi-omic studies of the human microbiome. © 2019, The Author(s).Description
Funding for microbiome science, human and otherwise, is now being coordinated among NIH Centers and Institutes (https://www.niaid. nih.gov/research/trans-nih-microbiome-working-group); other US government agencies including the National Science Foundation, Environmental Protection Agency, Department of Energy, National Institute of Standards and Technology, Department of Agriculture, National Oceanographic and Atmospheric Administration, National Aeronautics and Space Administration, and Department of Defense (https://commonfund.nih.gov/hmp/programhighlights); philanthropic organizations including the Bill and Melinda Gates Foundation, the March of Dimes, the Burroughs Wellcome Fund, the Sloan Foundation, the Keck Foundation, the Juvenile Diabetes Research Foundation, the Crohn’s and Colitis Foundation, and others; and industry and public– private partnerships.Sponsors
Funding from NIH grants UH2/UH3AI083263 and U54HD080784 (G.A.B., J.F.S., K. Jefferson) supported with funds from the Common Fund, the National Center for Complementary and Integrative Health, and the Office of Research on Women’s Health, grant U54DK102557 (C.H., R. Xavier), including funds from the Common Fund, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Center for Complementary and Integrative Health, and the Office of Dietary Supplements and grant U54DK102556 (M.P.S., G.M.W.), with funds from the Common Fund and the National Institute of Diabetes and Digestive and Kidney Diseases.Rights/Terms
Attribution 3.0 United StatesIdentifier to cite or link to this item
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066471013&origin=inward; http://hdl.handle.net/10713/9504ae974a485f413a2113503eed53cd6c53
10.1038/s41586-019-1238-8
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Except where otherwise noted, this item's license is described as Attribution 3.0 United States