Water Flow-NMR—A Prospective Contact-Free In-Line Analytical Tool for Continuous Biomanufacturing
MetadataShow full item record
AbstractContinuous manufacturing of biopharmaceuticals paves way to much faster and higher quality products compared to conventional batch manufacturing. One of the most critical impediments for a wider use of continuous biomanufacturing is the lack of noninvasive analytical tools for process monitoring. We have already demonstrated that water proton transverse relaxation rate R2(1H2O) could be used to noninvasively monitor a number of important aspects of a solute state, such as protein concentration and aggregation. Here, we present the results obtained using compact low-field benchtop flow-NMR instrument capable to measure R2(1H2O) within a wide range of flow rates. Our measurements confirmed the sensitivity of R2(1H2O) to flow rate changes, protein concentration, and the content of the protein aggregates in stressed protein solutions.
DescriptionPoster presented at the 7th Annual Practical Applications of NMR in Industry Conference (PANIC-2019), held March 3-7, in Hilton Head Island, South Carolina. Best Poster Award winner.
SponsorsNational Institute for Innovation in Manufacturing of Biopharmaceuticals (NIIMBL) grant QSP1.09
Rights/TermsAttribution-NonCommercial-NoDerivs 3.0 United States
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/9489
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States