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dc.contributor.authorNieman, G.F.
dc.contributor.authorAndrews, P.
dc.contributor.authorSatalin, J.
dc.date.accessioned2019-06-05T18:28:20Z
dc.date.available2019-06-05T18:28:20Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85047489596&doi=10.1186%2fs13054-018-2051-8&partnerID=40&md5=be01e84b78b76c2d0cc3d94b2c61e49e
dc.identifier.urihttp://hdl.handle.net/10713/9476
dc.description.abstractThe pathophysiology of acute respiratory distress syndrome (ARDS) results in heterogeneous lung collapse, edema-flooded airways and unstable alveoli. These pathologic alterations in alveolar mechanics (i.e. dynamic change in alveolar size and shape with each breath) predispose the lung to secondary ventilator-induced lung injury (VILI). It is our viewpoint that the acutely injured lung can be recruited and stabilized with a mechanical breath until it heals, much like casting a broken bone until it mends. If the lung can be "casted" with a mechanical breath, VILI could be prevented and ARDS incidence significantly reduced. Copyright 2018 The Author(s).en_US
dc.description.sponsorshipSupport was provided from NIH R01 HL131143.en_US
dc.description.urihttps://dx.doi.org/10.1186/s13054-018-2051-8en_US
dc.language.isoen-USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofCritical Care
dc.subjectAcute lung injuryen_US
dc.subjectInjurious mechanical ventilationen_US
dc.subjectTCAV protocolen_US
dc.titleAcute lung injury: How to stabilize a broken lungen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13054-018-2051-8
dc.identifier.pmid29793554


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