PublisherBioMed Central Ltd.
MetadataShow full item record
AbstractThe pathophysiology of acute respiratory distress syndrome (ARDS) results in heterogeneous lung collapse, edema-flooded airways and unstable alveoli. These pathologic alterations in alveolar mechanics (i.e. dynamic change in alveolar size and shape with each breath) predispose the lung to secondary ventilator-induced lung injury (VILI). It is our viewpoint that the acutely injured lung can be recruited and stabilized with a mechanical breath until it heals, much like casting a broken bone until it mends. If the lung can be "casted" with a mechanical breath, VILI could be prevented and ARDS incidence significantly reduced. Copyright 2018 The Author(s).
SponsorsSupport was provided from NIH R01 HL131143.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85047489596&doi=10.1186%2fs13054-018-2051-8&partnerID=40&md5=be01e84b78b76c2d0cc3d94b2c61e49e; http://hdl.handle.net/10713/9476
- Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury.
- Authors: Nieman GF, Satalin J, Kollisch-Singule M, Andrews P, Aiash H, Habashi NM, Gatto LA
- Issue date: 2017 Jun 1
- Acute lung injury and the acute respiratory distress syndrome: pathophysiology and treatment.
- Authors: Matuschak GM, Lechner AJ
- Issue date: 2010 Jul-Aug
- Impact of mechanical ventilation on the pathophysiology of progressive acute lung injury.
- Authors: Nieman GF, Gatto LA, Habashi NM
- Issue date: 2015 Dec 1
- Current knowledge of acute lung injury and acute respiratory distress syndrome.
- Authors: Dechert RE, Haas CF, Ostwani W
- Issue date: 2012 Sep
- Mechanical ventilation with lung protective strategies: what works?
- Authors: Haas CF
- Issue date: 2011 Jul