PublisherBioMed Central Ltd.
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AbstractThe pathophysiology of acute respiratory distress syndrome (ARDS) results in heterogeneous lung collapse, edema-flooded airways and unstable alveoli. These pathologic alterations in alveolar mechanics (i.e. dynamic change in alveolar size and shape with each breath) predispose the lung to secondary ventilator-induced lung injury (VILI). It is our viewpoint that the acutely injured lung can be recruited and stabilized with a mechanical breath until it heals, much like casting a broken bone until it mends. If the lung can be "casted" with a mechanical breath, VILI could be prevented and ARDS incidence significantly reduced. Copyright 2018 The Author(s).
SponsorsSupport was provided from NIH R01 HL131143.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85047489596&doi=10.1186%2fs13054-018-2051-8&partnerID=40&md5=be01e84b78b76c2d0cc3d94b2c61e49e; http://hdl.handle.net/10713/9476