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    Chaperonology: The third eye on brain gliomas

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    Author
    Graziano, F.
    Bavisotto, C.C.
    Gammazza, A.M.
    Date
    2018
    Journal
    Brain Sciences
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3390/brainsci8060110
    Abstract
    The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient's neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents. Copyright 2018 by the authors. Licensee MDPI, Basel, Switzerland.
    Keyword
    Chaperonology
    Chaperonotherapy
    Heat shock proteins
    High-grade gliomas
    Molecular chaperones
    Neuroimaging
    Neuromonitoring
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049187121&doi=10.3390%2fbrainsci8060110&partnerID=40&md5=0dadf114c0962d53f9ce263cab7234f8; http://hdl.handle.net/10713/9474
    ae974a485f413a2113503eed53cd6c53
    10.3390/brainsci8060110
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