Therapeutic and transmission-blocking efficacy of dihydroartemisinin/ piperaquine and chloroquine against Plasmodium vivax Malaria, Cambodia

Author
Popovici, J.
Vantaux, A.
Primault, L.
Date
2018
Journal
Emerging Infectious Diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Type
Article

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See at
https://dx.doi.org/10.3201/eid2408.170768
Abstract
We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months. Copyright 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
Sponsors
This study was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (grant R01 434 A103328) and the Institut Pasteur (grant PTR 2014-490). A.V. was supported by a Calmette and Yersin fellowship from the Institut Pasteur International Network.
Keyword
dihydroartemisinin/piperaquine
Chloroquine
Drug Therapy, Combination
Malaria, Vivax--prevention & control
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050398698&doi=10.3201%2feid2408.170768&partnerID=40&md5=5446b825781354cdb60ad5902847f51a; http://hdl.handle.net/10713/9468
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