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    Therapeutic and transmission-blocking efficacy of dihydroartemisinin/ piperaquine and chloroquine against Plasmodium vivax Malaria, Cambodia

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    Author
    Popovici, J.
    Vantaux, A.
    Primault, L.
    Date
    2018
    Journal
    Emerging Infectious Diseases
    Publisher
    Centers for Disease Control and Prevention (CDC)
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3201/eid2408.170768
    Abstract
    We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months. Copyright 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
    Sponsors
    This study was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (grant R01 434 A103328) and the Institut Pasteur (grant PTR 2014-490). A.V. was supported by a Calmette and Yersin fellowship from the Institut Pasteur International Network.
    Keyword
    dihydroartemisinin/piperaquine
    Chloroquine
    Drug Therapy, Combination
    Malaria, Vivax--prevention & control
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050398698&doi=10.3201%2feid2408.170768&partnerID=40&md5=5446b825781354cdb60ad5902847f51a; http://hdl.handle.net/10713/9468
    ae974a485f413a2113503eed53cd6c53
    10.3201/eid2408.170768
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