Contrast-enhanced endoscopic ultrasound for differentially diagnosing autoimmune pancreatitis and pancreatic cancer
JournalGut and Liver
PublisherEditorial Office of Gut and Liver
MetadataShow full item record
AbstractBackground/Aims: Differentially diagnosing focal-type autoimmune pancreatitis (f-AIP) and pancreatic cancer (PC) is challenging. Contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) may provide information for differentiating pancreatic masses. In this study, we evaluated the usefulness of CEH-EUS in differentiating f-AIP from PC. Methods: Data were collected prospectively and analyzed on patients who underwent CEH-EUS between May 2014 and May 2015. Eighty consecutive patients were diagnosed with f-AIP or PC. PC and f-AIP were compared for enhancement intensity, contrast agent distribution, and internal vasculature. Results: The study group comprised 53 PC patients and 27 f-AIP patients (17 with type-1 AIP [15 definite and two probable], two with probable type-2 AIP, and eight with AIP, not otherwise specified). Hyper- to iso-enhancement in the arterial phase (f-AIP, 89% vs PC, 13%; p<0.05), homogeneous contrast agent distribution (f-AIP, 81% vs PC, 17%; p<0.05), and absent irregular internal vessels (f-AIP, 85% vs PC, 30%; p<0.05) were observed more frequently in the f-AIP group. The combination of CEH-EUS and enhancement intensity, absent irregular internal vessels improved the specificity (94%) in differentiating f-AIP from PC. Conclusions: CEH-EUS may be a useful noninvasive modality for differentially diagnosing f-AIP and PC. Combined CEH-EUS findings could improve the specificity of CEH-EUS in differentiating f-AIP from PC. Copyright 2018 Editorial Office of Gut and Liver. All rights reserved.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053355859&doi=10.5009%2fgnl17391&partnerID=40&md5=30ebc3db9e0507637202547d527fa317; http://hdl.handle.net/10713/9465
- Novel quantitative perfusion analysis with contrast-enhanced harmonic EUS for differentiation of autoimmune pancreatitis from pancreatic carcinoma.
- Authors: Imazu H, Kanazawa K, Mori N, Ikeda K, Kakutani H, Sumiyama K, Hino S, Ang TL, Omar S, Tajiri H
- Issue date: 2012 Jul
- Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonography.
- Authors: Ishikawa T, Kawashima H, Ohno E, Mizutani Y, Fujishiro M
- Issue date: 2021 Oct
- Differentiation of focal-type autoimmune pancreatitis from pancreatic carcinoma: assessment by multiphase contrast-enhanced CT.
- Authors: Furuhashi N, Suzuki K, Sakurai Y, Ikeda M, Kawai Y, Naganawa S
- Issue date: 2015 May
- Focal autoimmune pancreatitis: radiological characteristics help to distinguish from pancreatic cancer.
- Authors: Sun GF, Zuo CJ, Shao CW, Wang JH, Zhang J
- Issue date: 2013 Jun 21
- Comparison of endoscopic retrograde cholangiopancreatography with papillary biopsy and endoscopic ultrasound-guided pancreatic biopsy in the diagnosis of autoimmune pancreatitis.
- Authors: Jung JG, Lee JK, Lee KH, Lee KT, Woo YS, Paik WH, Park DH, Lee SS, Seo DW, Lee SK, Kim MH
- Issue date: 2015 May-Jun