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    Exposure to concentrated ambient PM 2.5 compromises spermatogenesis in a mouse model: Role of suppression of hypothalamus-pituitary-gonads axis

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    Author
    Qiu, L.
    Chen, M.
    Wang, X.
    Date
    2018
    Journal
    Toxicological Sciences
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1093/TOXSCI/KFX261
    Abstract
    Epidemiological studies link ambient fine particulate matter (PM2.5) pollution to abnormalities in the male reproductive system. However, few toxicological studies have investigated this potentially important adverse effect of PM2.5 pollution. Therefore, in the present study, we analyzed the effects of PM2.5 exposure on spermatogenesis and hypothalamic-pituitary-gonadal (HPG) axis in a murine model. Fourteen male C57BL/6J mice were subjected to a 4-month exposure to filtered air or concentrated ambient PM2.5 (CAP). Their sperm count, testicular histology, spermatogenic parameters, and the major components of HPG axis were assessed. Exposure to CAP significantly reduced sperm count in the epididymis. This was accompanied by Sertoli cell vacuolization, immature germ cell dislocation, and decreases in pachytene spermatocytes and round spermatids of stage VII seminiferous tubules, suggesting a marked impairment of spermatogenesis in these mice. This impairment of spermatogenesis appeared to be attributable to a suppression of HPG axis subsequent to CAP exposure-induced hypothalamic inflammation, as exposure to CAP significantly increased TNFα and IL1b mRNA levels and meanwhile decreased gonadotropin-releasing hormone mRNA expression in the hypothalamus. Moreover, CAP exposure significantly reduced circulating testosterone and follicle-stimulating hormone, testicular testosterone and mRNA expression of follicle-stimulating hormone target gene SHBG and luteinizing hormone target genes P450scc, 17βHSD, and StAR. The present data demonstrate that exposure to ambient PM2.5 impairs spermatogenesis in murine model, raising the concern over effects of ambient PM2.5 pollution on the male reproductive function. Copyright The Author 2017. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved.
    Sponsors
    Science Foundation of China (Grant No. 81302452 to L.Q., 81270342 to Z.Y., 81500216 to M.C., 21407082 to X.W.), and Scientific Research Starting Foundation for The Doctoral Researcher of Nantong University (No. 14B14).
    Keyword
    Ambient fine particulate matter (PM 2.5 )
    Hypothalamic-pituitary-gonadal axis
    Inflammation
    Male reproductive system
    Spermatogenesis
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049152275&doi=10.1093%2fTOXSCI%2fKFX261&partnerID=40&md5=8df463b392dc2e75a2c63d36e845fe63; http://hdl.handle.net/10713/9445
    ae974a485f413a2113503eed53cd6c53
    10.1093/TOXSCI/KFX261
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