Show simple item record

dc.contributor.authorGrattan, L.M.
dc.contributor.authorBoushey, C.J.
dc.contributor.authorLiang, Y.
dc.date.accessioned2019-06-05T18:28:16Z
dc.date.available2019-06-05T18:28:16Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85042768411&doi=10.3390%2ftoxins10030103&partnerID=40&md5=17ee3a55bb42df2167cf9ff2783b0c53
dc.identifier.urihttp://hdl.handle.net/10713/9430
dc.description.abstractDomoic Acid (DA) is a marine-based neurotoxin. Dietary exposure to high levels of DA via shellfish consumption has been associated with Amnesic Shellfish Poisoning, with milder memory decrements found in Native Americans (NAs) with repetitive, lower level exposures. Despite its importance for protective action, the clinical relevance of these milder memory problems remains unknown. The purpose of this study was to determine whether repeated, lower-level exposures to DA impact everyday memory (EM), i.e., the frequency of memory failures in everyday life. A cross-sectional sample of 60 NA men and women from the Pacific NW was studied with measures of dietary exposure to DA via razor clam (RC) consumption and EM. Findings indicated an association between problems with EM and elevated consumption of RCs with low levels of DA throughout the previous week and past year after controlling for age, sex, and education. NAs who eat a lot of RCs with presumably safe levels of DA are at risk for clinically significant memory problems. Public health outreach to minimize repetitive exposures are now in place and were facilitated by the use of community-based participatory research methods, with active involvement of state regulatory agencies, tribe leaders, and local physicians. Copyright 2018 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipSupport for this work came from a National Institute of Environmental Health Sciences grant (NIEHS: 5R01ES012459-05S1) awarded to Grattan. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NIEHS. This project was also partially supported by the National Cancer Institute P30 C071789.en_US
dc.description.urihttps://dx.doi.org/10.3390/toxins10030103en_US
dc.language.isoen-USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofToxins
dc.subjectAmnesic Shellfish Poisoningen_US
dc.subjectDomoic aciden_US
dc.subjectDomoic acid neurotoxicityen_US
dc.subjectEnvironmental public healthen_US
dc.subjectEveryday memoryen_US
dc.subjectHarmful algal bloomsen_US
dc.subjectNative American healthen_US
dc.subjectPseudo-nitzchiaen_US
dc.titleRepeated dietary exposure to low levels of domoic acid and problems with everyday memory: Research to public health outreachen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/toxins10030103
dc.identifier.pmid29495583


This item appears in the following Collection(s)

Show simple item record