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dc.contributor.authorZhang, H.
dc.contributor.authorGong, D.
dc.contributor.authorNi, L.
dc.date.accessioned2019-06-05T18:28:14Z
dc.date.available2019-06-05T18:28:14Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85052456593&doi=10.1159%2f000492093&partnerID=40&md5=643ac7cbd68cea302c97053f72dc60e8
dc.identifier.urihttp://hdl.handle.net/10713/9412
dc.description.abstractBackground/Aims: Elabela (ELA) or Toddler is a recently identified hormone that plays a crucial role in embryonic development through the activation of the apelin receptor (APJ). Our previous study indicated that ELA is highly expressed in adult kidney and the ELA receptor signaling pathway is functional in mammalian systems. Whereas nothing is yet known regarding ELA and diabetic kidney disease (DKD). Here, we evaluated the relationship between serum ELA levels and albuminuria in patients with type 2 diabetes (T2D). Methods: An observational study involving 80 patients divided into groups according to their baseline urinary albumin/creatinine ratio (ACR): Group 1 (ACR ≤ 29 mg/g), Group 2 (ACR = 30–299 mg/g), Group 3 (ACR ≥ 300 mg/g with normal serum creatinine), and Group 4 (ACR ≥ 300 mg/g with increased serum creatinine). The demographic, clinical, and biochemical variables including serum ELA were obtained or measured through disease history, physical examination, or laboratory evidence. Results: The results showed that the serum ELA levels decreased gradually with the deterioration of DKD from the stages of normal albuminuria, microalbuminuria, macroalbuminuria, to macroalbuminuria and elevated serum creatinine. In addition, ELA had a significantly negative correlation with ACR (r = -0.561, P < 0.001), retinopathy (r = -0.424, P < 0.001), serum creatinine (r = -0.269, P = 0.016), SBP (r = -0.249, P = 0.026), DBP (r = -0.261, P = 0.020) and a positive correlation with eGFR (r = 0.318, P = 0.004). Furthermore, stepwise multiple linear regression analysis showed that ACR, retinopathy, and LDL-C were considered the most relevant variables to ELA, and ELA, retinopathy, eGFR, and age were important predictors for ACR (t = -4.546, P = 0.000). Conclusions: To our knowledge, this is the first study to explore the clinical relationship between ELA levels and CKD. Decreased serum ELA levels might be a significant clinical predictor in patients with DKD or even as a promising agent for treating CKD patients. Copyright 2018 The Author(s). Published by S. Karger AG, Basel.en_US
dc.description.sponsorshipThis study was supported by the National Natural Science Foundation of China Grant Award, Jiangsu Provincial Commission of Health and Family Planning, China and Jiangsu Provincial Key Laboratory of Automotive Engineering, China.en_US
dc.description.urihttps://dx.doi.org/10.1159/000492093en_US
dc.language.isoen-USen_US
dc.publisherS. Karger AGen_US
dc.relation.ispartofCellular Physiology and Biochemistry
dc.subjectAlbuminuriaen_US
dc.subjectDiabetic Kidney Disease (DKD)en_US
dc.subjectElabela (ELA)en_US
dc.titleSerum Elabela/Toddler Levels Are Associated with Albuminuria in Patients with Type 2 Diabetesen_US
dc.typeArticleen_US
dc.identifier.doi10.1159/000492093
dc.identifier.pmid30048993


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