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dc.contributor.authorMa, B.
dc.contributor.authorMcComb, E.
dc.contributor.authorGajer, P.
dc.date.accessioned2019-06-05T18:28:13Z
dc.date.available2019-06-05T18:28:13Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056726890&doi=10.3389%2ffmicb.2018.02755&partnerID=40&md5=25d0f6d3aebf1ed1f38c75226b6b18a8
dc.identifier.urihttp://hdl.handle.net/10713/9404
dc.description.abstractIntestinal barrier immaturity, or "leaky gut," is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. However, the impact of intestinal microbiota development on intestinal mucosal barrier maturation has not been evaluated in this population. In this study, we investigated a longitudinally sampled cohort of 38 preterm infants < 33 weeks gestation monitored for intestinal permeability (IP) and fecal microbiota during the first 2 weeks of life. Rapid decrease in IP indicating intestinal barrier function maturation correlated with significant increase in community diversity. In particular, members of the Clostridiales and Bifidobacterium were highly transcriptionally active, and progressively increasing abundance in Clostridiales was significantly associated with decreased intestinal permeability. Further, neonatal factors previously identified to promote intestinal barrier maturation, including early exclusive breastmilk feeding and shorter duration antibiotic exposure, associate with the early colonization of the intestinal microbiota by members of the Clostridiales, which altogether are associated with improved intestinal barrier function in preterm infants. Copyright Copyright 2018 Ma, McComb, Gajer, Yang, Humphrys, Okogbule-Wonodi, Fasano, Ravel and Viscardi.en_US
dc.description.urihttps://dx.doi.org/10.3389/fmicb.2018.02755en_US
dc.language.isoen-USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Microbiology
dc.subjectBifidobacteriumen_US
dc.subjectBreastmilk feedingen_US
dc.subjectClostridialesen_US
dc.subjectIntestinal microbiotaen_US
dc.subjectIntestinal permeabilityen_US
dc.subjectLeaky guten_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectPreterm infanten_US
dc.titleMicrobial biomarkers of intestinal barrier maturation in preterm infantsen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fmicb.2018.02755


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