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    Microbial biomarkers of intestinal barrier maturation in preterm infants

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    Author
    Ma, B.
    McComb, E.
    Gajer, P.
    Date
    2018
    Journal
    Frontiers in Microbiology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3389/fmicb.2018.02755
    Abstract
    Intestinal barrier immaturity, or "leaky gut," is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. However, the impact of intestinal microbiota development on intestinal mucosal barrier maturation has not been evaluated in this population. In this study, we investigated a longitudinally sampled cohort of 38 preterm infants < 33 weeks gestation monitored for intestinal permeability (IP) and fecal microbiota during the first 2 weeks of life. Rapid decrease in IP indicating intestinal barrier function maturation correlated with significant increase in community diversity. In particular, members of the Clostridiales and Bifidobacterium were highly transcriptionally active, and progressively increasing abundance in Clostridiales was significantly associated with decreased intestinal permeability. Further, neonatal factors previously identified to promote intestinal barrier maturation, including early exclusive breastmilk feeding and shorter duration antibiotic exposure, associate with the early colonization of the intestinal microbiota by members of the Clostridiales, which altogether are associated with improved intestinal barrier function in preterm infants. Copyright Copyright 2018 Ma, McComb, Gajer, Yang, Humphrys, Okogbule-Wonodi, Fasano, Ravel and Viscardi.
    Keyword
    Bifidobacterium
    Breastmilk feeding
    Clostridiales
    Intestinal microbiota
    Intestinal permeability
    Leaky gut
    Necrotizing enterocolitis
    Preterm infant
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056726890&doi=10.3389%2ffmicb.2018.02755&partnerID=40&md5=25d0f6d3aebf1ed1f38c75226b6b18a8; http://hdl.handle.net/10713/9404
    ae974a485f413a2113503eed53cd6c53
    10.3389/fmicb.2018.02755
    Scopus Count
    Collections
    UMB Open Access Articles 2018

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