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    A new category stent with novel polyphosphazene surface modification

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    Author
    Mori, H.
    Jinnouchi, H.
    Diljon, C.
    Date
    2018
    Journal
    Future Cardiology
    Publisher
    Future Medicine Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.2217/fca-2017-0103
    Abstract
    The COBRA-PzF™ (CeloNova BioSciences, Inc., TX, USA) is a new type of coronary stent composed of a cobalt chromium metallic backbone surrounded by a nanothin layer of Polyzene-F (PzF) without any added drug. Evidence from basic studies supports antithrombotic and anti-inflammatory properties for the PzF surface coating. Preclinical studies support the thromboresistance of PzF-coated surfaces and clinical studies have shown good outcomes for patients receiving this device with very low rates of stent thrombosis. COBRA-PzF may be especially useful in patients at high risk for bleeding. Ongoing clinical trials will determine whether shortening the duration of dual antiplatelet therapy to less than 1 month is feasible and these data may represent a new paradigm with regards to patients at high risk for bleeding. Copyright 2018 Future Medicine Ltd.
    Keyword
    bleeding
    drug-eluting stent
    polymer
    stent
    stent thrombosis
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048968939&doi=10.2217%2ffca-2017-0103&partnerID=40&md5=32a19e81bc76978b92766305a262d236; http://hdl.handle.net/10713/9386
    ae974a485f413a2113503eed53cd6c53
    10.2217/fca-2017-0103
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    UMB Open Access Articles 2018

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