Date
2018Journal
Journal of Experimental and Clinical Cancer ResearchPublisher
BioMed Central Ltd.Type
Article
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Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but also tRNA derivatives generated by the specific cleavage of pre- and mature tRNAs in the progression of cancer. Accumulating evidence had identified that certain tRNAs and tRNA derivatives were involved in proliferation, metastasis and invasiveness of cancer cell, as well as tumor growth and angiogenesis in several malignant human tumors. This paper reviews the importance of the dysregulation of tRNAs and tRNA derivatives during the development of cancer, such as breast cancer, lung cancer, and melanoma, aiming at a better understanding of the tumorigenesis and providing new ideas for the treatment of these cancers. Copyright 2018 The Author(s).Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046718726&doi=10.1186%2fs13046-018-0745-z&partnerID=40&md5=3f846a51edc4f32c7867d4c38a9823f7; http://hdl.handle.net/10713/9305ae974a485f413a2113503eed53cd6c53
10.1186/s13046-018-0745-z
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