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    The dysregulation of tRNAs and tRNA derivatives in cancer

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    Author
    Huang, S.-Q.
    Sun, B.
    Xiong, Z.-P.
    Date
    2018
    Journal
    Journal of Experimental and Clinical Cancer Research
    Publisher
    BioMed Central Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1186/s13046-018-0745-z
    Abstract
    Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but also tRNA derivatives generated by the specific cleavage of pre- and mature tRNAs in the progression of cancer. Accumulating evidence had identified that certain tRNAs and tRNA derivatives were involved in proliferation, metastasis and invasiveness of cancer cell, as well as tumor growth and angiogenesis in several malignant human tumors. This paper reviews the importance of the dysregulation of tRNAs and tRNA derivatives during the development of cancer, such as breast cancer, lung cancer, and melanoma, aiming at a better understanding of the tumorigenesis and providing new ideas for the treatment of these cancers. Copyright 2018 The Author(s).
    Keyword
    Breast cancer
    Lung cancer
    Melanoma
    tRNA
    tRNA derivatives
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046718726&doi=10.1186%2fs13046-018-0745-z&partnerID=40&md5=3f846a51edc4f32c7867d4c38a9823f7; http://hdl.handle.net/10713/9305
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13046-018-0745-z
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