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    Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial

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    Author
    Wang, H.
    Agarwal, P.
    Zhao, G.
    Date
    2018
    Journal
    ACS Central Science
    Publisher
    American Chemical Society
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1021/acscentsci.8b00050
    Abstract
    Drug resistance due to overexpression of membrane transporters in cancer cells and the existence of cancer stem cells (CSCs) is a major hurdle to effective and safe cancer chemotherapy. Nanoparticles have been explored to overcome cancer drug resistance. However, drug slowly released from nanoparticles can still be efficiently pumped out of drug-resistant cells. Here, a hybrid nanoparticle of phospholipid and polymers is developed to achieve cold-triggered burst release of encapsulated drug. With ice cooling to below ∼12 °C for both burst drug release and reduced membrane transporter activity, binding of the drug with its target in drug-resistant cells is evident, while it is minimal in the cells kept at 37 °C. Moreover, targeted drug delivery with the cold-responsive nanoparticles in combination with ice cooling not only can effectively kill drug-resistant ovarian cancer cells and their CSCs in vitro but also destroy both subcutaneous and orthotopic ovarian tumors in vivo with no evident systemic toxicity. Copyright Copyright 2018 American Chemical Society.
    Sponsors
    This work was partially supported by American Cancer Society (#120936-RSG-11-109-01-CDD) and NIH (R01CA206366).
    Keyword
    Drug Resistance, Neoplasm
    Nanoparticles--therapeutic use
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047553075&doi=10.1021%2facscentsci.8b00050&partnerID=40&md5=d84322b89d42a213eea5f0c43f93c67e; http://hdl.handle.net/10713/9304
    ae974a485f413a2113503eed53cd6c53
    10.1021/acscentsci.8b00050
    Scopus Count
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    UMB Open Access Articles 2018

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