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    Physician-reported benefits and barriers to clinical implementation of genomic medicine: A multi-site ignite-network survey

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    Author
    Obeng, A.O.
    Fei, K.
    Levy, K.D.
    Date
    2018
    Journal
    Journal of Personalized Medicine
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3390/jpm8030024
    Abstract
    Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians' institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically "high-risk" patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians. Copyright 2018 by the authors
    Sponsors
    Funding: This study is supported by National Human Genome Research Institute or the National Institutes of Health (NHGRI) (5U01HG007278, U01HG006380, 5U01HG007762, U01HG007775, U01HG007269 and U01HG07253) and National Center for Advancing Translational Sciences (NCATS) (UL1TR000067). AOO is also supported by National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI) 3U01HG008701-02S1 (eMERGE-PGx).
    Keyword
    Barriers
    Chronic disease
    Clinical implementation
    Clinical utility
    Genetic medicine
    Genetic testing
    Pharmacogenetics
    Physician attitudes
    Physician education
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054713893&doi=10.3390%2fjpm8030024&partnerID=40&md5=14c2b9f4478bdb52e8dd2c480713fa36; http://hdl.handle.net/10713/9295
    ae974a485f413a2113503eed53cd6c53
    10.3390/jpm8030024
    Scopus Count
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