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dc.contributor.authorWhite, M.G.
dc.contributor.authorPanicker, M.
dc.contributor.authorMu, C.
dc.date.accessioned2019-05-21T18:56:23Z
dc.date.available2019-05-21T18:56:23Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85041673569&doi=10.1016%2fj.celrep.2017.12.023&partnerID=40&md5=8ed53ae6868bec8493f50aacf8dfc862
dc.identifier.urihttp://hdl.handle.net/10713/9264
dc.description.abstractCognitive abilities, such as volitional attention, operate under top-down, executive frontal cortical control of hierarchically lower structures. The circuit mechanisms underlying this process are unresolved. The claustrum possesses interconnectivity with many cortical areas and, thus, is hypothesized to orchestrate the cortical mantle for top-down control. Whether the claustrum receives top-down input and how this input may be processed by the claustrum have yet to be formally tested, however. We reveal that a rich anterior cingulate cortex (ACC) input to the claustrum encodes a preparatory top-down information signal on a five-choice response assay that is necessary for optimal task performance. We further show that ACC input monosynaptically targets claustrum inhibitory interneurons and spiny glutamatergic projection neurons, the latter of which amplify ACC input in a manner that is powerfully constrained by claustrum inhibitory microcircuitry. These results demonstrate ACC input to the claustrum is critical for top-down control guiding action. White et al. show that anterior cingulate cortex (ACC) input to the claustrum encodes a top-down preparatory signal on a 5-choice response assay that is critical for task performance. Claustrum microcircuitry amplifies top-down ACC input in a frequency-dependent manner for eventual propagation to the cortex for cognitive control of action. Copyright 2017 The Authorsen_US
dc.description.sponsorshipThis work has been supported by National Institute on Alcohol Abuse and Alcoholism grants K22AA021414 and R01AA024845, Whitehall Foundation grant 2014-12-68, National Institute of Mental Health grant F31MH112350 , National Institute of General Medical Sciences grant T32GM008181, and National Institute of Neurological Disorders and Stroke grant T32NS063391.en_US
dc.description.urihttps://dx.doi.org/10.1016/j.celrep.2017.12.023en_US
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofCell Reports
dc.subject5CSRTTen_US
dc.subjectattentionen_US
dc.subjectbottom-upen_US
dc.subjectfiber photometryen_US
dc.subjectmicrocircuiten_US
dc.subjectmotor corticesen_US
dc.subjectoptogeneticsen_US
dc.subjectsensory corticesen_US
dc.titleAnterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Controlen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.celrep.2017.12.023
dc.identifier.pmid29298436


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