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    Probing molecular insights into Zika virus–host interactions

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    Author
    Lee, I.
    Bos, S.
    Li, G.
    Date
    2018
    Journal
    Viruses
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.3390/v10050233
    Abstract
    The recent Zika virus (ZIKV) outbreak in the Americas surprised all of us because of its rapid spread and association with neurologic disorders including fetal microcephaly, brain and ocular anomalies, and Guillain–Barré syndrome. In response to this global health crisis, unprecedented and world-wide efforts are taking place to study the ZIKV-related human diseases. Much has been learned about this virus in the areas of epidemiology, genetic diversity, protein structures, and clinical manifestations, such as consequences of ZIKV infection on fetal brain development. However, progress on understanding the molecular mechanism underlying ZIKV-associated neurologic disorders remains elusive. To date, we still lack a good understanding of; (1) what virologic factors are involved in the ZIKV-associated human diseases; (2) which ZIKV protein(s) contributes to the enhanced viral pathogenicity; and (3) how do the newly adapted and pandemic ZIKV strains alter their interactions with the host cells leading to neurologic defects? The goal of this review is to explore the molecular insights into the ZIKV-host interactions with an emphasis on host cell receptor usage for viral entry, cell innate immunity to ZIKV, and the ability of ZIKV to subvert antiviral responses and to cause cytopathic effects. We hope this literature review will inspire additional molecular studies focusing on ZIKV-host Interactions. Copyright 2018 by the authors. Licensee MDPI, Basel, Switzerland.
    Keyword
    Antiviral responses
    Cell surface receptors
    Cytopathic effects
    Microcephaly
    Viral counteraction
    Viral pathogenesis
    Zika virus
    ZIKV-associated neurologic disorders
    ZIKV-host interactions
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047153583&doi=10.3390%2fv10050233&partnerID=40&md5=ba4fc9053a07237a00b31dd0b5c3a236; http://hdl.handle.net/10713/9244
    ae974a485f413a2113503eed53cd6c53
    10.3390/v10050233
    Scopus Count
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    UMB Open Access Articles 2018

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