Show simple item record

dc.contributor.authorZhang, N.
dc.contributor.authorZhang, K.
dc.contributor.authorWeir, M.D.
dc.date.accessioned2019-05-21T18:56:21Z
dc.date.available2019-05-21T18:56:21Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85048290705&doi=10.1038%2fs41368-018-0019-9&partnerID=40&md5=899778dc1130b382aef7e552c40d917b
dc.identifier.urihttp://hdl.handle.net/10713/9232
dc.description.abstractBiofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability. A protein-repellent agent (MPC) and antibacterial agent (DMAHDM) were added to a Scotchbond multi-purpose (SBMP) primer and adhesive. Specimens were stored in water at 37 °C for 1, 30, 90, or 180 days (d). At the end of each time period, the dentin bond strength and protein-repellent and antibacterial properties were evaluated. Protein attachment onto resin specimens was measured by the micro-bicinchoninic acid approach. A dental plaque microcosm biofilm model was used to test the biofilm response. The SBMP + MPC + DMAHDM group showed no decline in dentin bond strength after water-aging for 6 months, which was significantly higher than that of the control (P<0.05). The SBMP + MPC + DMAHDM group had protein adhesion that was only 1/20 of that of the SBMP control (P<0.05). Incorporation of MPC and DMAHDM into SBMP provided a synergistic effect on biofilm reduction. The antibacterial effect and resistance to protein adsorption exhibited no decrease from 1 to 180 d (P>0.1). In conclusion, a bonding agent with MPC and DMAHDM achieved a durable dentin bond strength and long-term resistance to proteins and oral bacteria. The novel dental bonding agent is promising for applications in preventive and restorative dentistry to reduce biofilm formation at the tooth-restoration margin.en_US
dc.description.urihttps://dx.doi.org/10.1038/s41368-018-0019-9en_US
dc.language.isoen_USen_US
dc.publisherSpringerNatureen_US
dc.relation.ispartofInternational journal of oral science
dc.subjectdimethylaminohexadecyl methacrylate (DMAHDM)en_US
dc.subject2-methacryloyloxyethyl phosphorylcholine (MPC)en_US
dc.subject.meshBiofilmsen_US
dc.subject.meshDental Bondingen_US
dc.subject.meshDental Caries Susceptibilityen_US
dc.subject.meshDental Restoration, Permanenten_US
dc.titleEffects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agenten_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41368-018-0019-9
dc.identifier.pmid29925870


This item appears in the following Collection(s)

Show simple item record