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dc.contributor.authorDudics, S.
dc.contributor.authorLangan, D.
dc.contributor.authorMeka, R.R.
dc.date.accessioned2019-05-21T18:56:20Z
dc.date.available2019-05-21T18:56:20Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85052494425&doi=10.3390%2fijms19092508&partnerID=40&md5=3cb1e281825db05d15d14610dde531b6
dc.identifier.urihttp://hdl.handle.net/10713/9224
dc.description.abstractRheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and bone. Several anti-inflammatory and disease-modifying drugs are available for RA therapy. However, the prolonged use of these drugs is associated with severe side effects. Furthermore, these drugs are effective only in a proportion of RA patients. Hence, there is a need to search for new therapeutic agents that are effective yet safe. Interestingly, a variety of herbs and other natural products offer a vast resource for such anti-arthritic agents. We discuss here the basic features of RA pathogenesis; the commonly used animal models of RA; the mainstream drugs used for RA; the use of well-characterized natural products possessing anti-arthritic activity; the application of nanoparticles for efficient delivery of such products; and the interplay between dietary products and the host microbiome for maintenance of health and disease induction. We believe that with several advances in the past decade in the characterization and functional studies of natural products, the stage is set for widespread clinical testing and/or use of these products for the treatment of RA and other diseases. Copyright 2018 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.urihttps://dx.doi.org/10.3390/ijms19092508en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.subjectAdjuvant-induced arthritisen_US
dc.subjectArthritisen_US
dc.subjectCelastrolen_US
dc.subjectCurcuminen_US
dc.subjectDietary supplementsen_US
dc.subjectEGCGen_US
dc.subjectGreen teaen_US
dc.subjectInflammationen_US
dc.subjectLiposomesen_US
dc.subjectMicrobiomeen_US
dc.subjectNanoparticlesen_US
dc.subjectNatural productsen_US
dc.subjectResveratrolen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectTargeted deliveryen_US
dc.subjectTraditional medicineen_US
dc.subjectTripterygium wilfordiien_US
dc.subjectTriptolideen_US
dc.titleNatural products for the treatment of autoimmune arthritis: Their mechanisms of action, targeted delivery, and interplay with the host microbiomeen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms19092508
dc.identifier.pmid30149545


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