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dc.contributor.authorWilkinson, A.N.
dc.contributor.authorAfshar, M.
dc.contributor.authorAli, O.
dc.date.accessioned2019-05-17T13:21:18Z
dc.date.available2019-05-17T13:21:18Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053707300&doi=10.1177%2f0300060518782020&partnerID=40&md5=bd6b3926f9b29473a0f36e5da5723eae
dc.identifier.urihttp://hdl.handle.net/10713/9218
dc.description.abstractObjective: Alcohol is a hypnotic that modifies immune function, specifically the cytokines interferon gamma (IFN-γ) and interleukin 2 (IL-2). We evaluated the association between unscheduled napping and acute alcohol-induced augmentation of IFN-γ and IL-2 expression. Methods: In this prospective, observational pilot study, volunteers completed questionnaires on sleep quality, alcohol use, and hangover characteristics. Actigraph recordings began three nights before and continued for four nights after study initiation. Napping was recorded by actigraphy and self-reporting. A weight-based dose of 100-proof vodka was consumed, and the blood alcohol content (BAC) and phytohemagglutinin-M stimulated cytokine level were measured before and 20 minutes, 2 hours, and 5 hours after binge consumption. Results: Ten healthy volunteers participated (mean age, 34.4 ± 2.3 years; mean body mass index, 23.9 ± 4.6 kg/m2; 60% female). The mean 20-minute BAC was 137.7 ± 40.7 mg/dL. Seven participants took an unscheduled nap. The ex vivo IFN-γ and IL-2 levels significantly increased at all time points after binge consumption in the nappers, but not in the non-nappers. Conclusion: Augmented IFN-γ and IL-2 levels are associated with unscheduled napping after binge alcohol consumption. Further studies are needed to clarify the associations among alcohol consumption, sleep disruption, and inflammatory mediators. Copyright The Author(s) 2018.en_US
dc.description.urihttps://dx.doi.org/10.1177/0300060518782020en_US
dc.language.isoen_USen_US
dc.publisherSAGE Publications Ltden_US
dc.relation.ispartofJournal of International Medical Research
dc.subjectalcoholen_US
dc.subjecthypnoticsen_US
dc.subjectImmunityen_US
dc.subjectinsomniaen_US
dc.subjectpharmacologyen_US
dc.subjectsleepen_US
dc.titleEffects of binge alcohol consumption on sleep and inflammation in healthy volunteersen_US
dc.typeArticleen_US
dc.identifier.doi10.1177/0300060518782020
dc.identifier.pmid29976100


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