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    Effects of binge alcohol consumption on sleep and inflammation in healthy volunteers

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    Author
    Wilkinson, A.N.
    Afshar, M.
    Ali, O.
    Date
    2018
    Journal
    Journal of International Medical Research
    Publisher
    SAGE Publications Ltd
    Type
    Article
    
    Metadata
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    See at
    https://dx.doi.org/10.1177/0300060518782020
    Abstract
    Objective: Alcohol is a hypnotic that modifies immune function, specifically the cytokines interferon gamma (IFN-γ) and interleukin 2 (IL-2). We evaluated the association between unscheduled napping and acute alcohol-induced augmentation of IFN-γ and IL-2 expression. Methods: In this prospective, observational pilot study, volunteers completed questionnaires on sleep quality, alcohol use, and hangover characteristics. Actigraph recordings began three nights before and continued for four nights after study initiation. Napping was recorded by actigraphy and self-reporting. A weight-based dose of 100-proof vodka was consumed, and the blood alcohol content (BAC) and phytohemagglutinin-M stimulated cytokine level were measured before and 20 minutes, 2 hours, and 5 hours after binge consumption. Results: Ten healthy volunteers participated (mean age, 34.4 ± 2.3 years; mean body mass index, 23.9 ± 4.6 kg/m2; 60% female). The mean 20-minute BAC was 137.7 ± 40.7 mg/dL. Seven participants took an unscheduled nap. The ex vivo IFN-γ and IL-2 levels significantly increased at all time points after binge consumption in the nappers, but not in the non-nappers. Conclusion: Augmented IFN-γ and IL-2 levels are associated with unscheduled napping after binge alcohol consumption. Further studies are needed to clarify the associations among alcohol consumption, sleep disruption, and inflammatory mediators. Copyright The Author(s) 2018.
    Keyword
    alcohol
    hypnotics
    Immunity
    insomnia
    pharmacology
    sleep
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053707300&doi=10.1177%2f0300060518782020&partnerID=40&md5=bd6b3926f9b29473a0f36e5da5723eae; http://hdl.handle.net/10713/9218
    ae974a485f413a2113503eed53cd6c53
    10.1177/0300060518782020
    Scopus Count
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    UMB Open Access Articles 2018

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