JournalGenome Biology and Evolution
PublisherOxford University Press
MetadataShow full item record
AbstractWhile typically a flea parasite and opportunistic human pathogen, the presence of Rickettsia felis (strain LSU-Lb) in the non-bloodfeeding, parthenogenetically reproducing booklouse, Liposcelis bostrychophila, provides a system to ascertain factors governing not only host transitions but also obligate reproductive parasitism (RP). Analysis of plasmid pLbAR, unique to R. felis str. LSU-Lb, revealed a toxin-antitoxin module with similar features to prophage-encoded toxin-antitoxin modules utilized by parasitic Wolbachia strains to induce another form of RP, cytoplasmic incompatibility, in their arthropod hosts. Curiously, multiple deubiquitinase and nuclease domains of the large (3,841 aa) pLbAR toxin, as well the entire antitoxin, facilitated the detection of an assortment of related proteins from diverse intracellular bacteria, including other reproductive parasites. Our description of these remarkable components of the intracellular mobilome, including their presence in certain arthropod genomes, lends insight on the evolution of RP, while invigorating research on parasite-mediated biocontrol of arthropod-borne viral and bacterial pathogens. Copyright The Author(s) 2018.
SponsorsThis work was supported with funds from the National Institute of Health/ National Institute of Allergy and Infectious Diseases grants (R01AI017828 and R01AI126853 to A.F.A., R21AI26108 to J.J.G. and M.S.R., and AI22672 to K.R.M.).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054888213&doi=10.1093%2fgbe%2fevy159&partnerID=40&md5=a1dd26c9623f595d4f8b598aa716a87c; http://hdl.handle.net/10713/9184
- Genomic diversification in strains of Rickettsia felis Isolated from different arthropods.
- Authors: Gillespie JJ, Driscoll TP, Verhoeve VI, Utsuki T, Husseneder C, Chouljenko VN, Azad AF, Macaluso KR
- Issue date: 2014 Dec 4
- Effect of Rickettsia felis Strain Variation on Infection, Transmission, and Fitness in the Cat Flea (Siphonaptera: Pulicidae).
- Authors: Healy SP, Brown LD, Hagstrom MR, Foil LD, Macaluso KR
- Issue date: 2017 Jul 1
- Evolutionary Genetics of Cytoplasmic Incompatibility Genes cifA and cifB in Prophage WO of Wolbachia.
- Authors: Lindsey ARI, Rice DW, Bordenstein SR, Brooks AW, Bordenstein SR, Newton ILG
- Issue date: 2018 Feb 1
- Rickettsia felis infection in a common household insect pest, Liposcelis bostrychophila (Psocoptera: Liposcelidae).
- Authors: Behar A, McCormick LJ, Perlman SJ
- Issue date: 2010 Apr
- Computational evidence for antitoxins associated with RelE/ParE, RatA, Fic, and AbiEii-family toxins in Wolbachia genomes.
- Authors: Fallon AM
- Issue date: 2020 Jul