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    Coronary Artery Calcification and its Progression: What Does it Really Mean?

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    Author
    Mori, H.
    Torii, S.
    Kutyna, M.
    Date
    2018
    Journal
    JACC: Cardiovascular Imaging
    Publisher
    Elsevier Inc.
    Type
    Article
    
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    See at
    https://dx.doi.org/10.1016/j.jcmg.2017.10.012
    Abstract
    Coronary artery calcification is concomitant with the development of advanced atherosclerosis. Coronary artery calcification pathologically begins as microcalcifications (0.5 to 15.0 μm) and grows into larger calcium fragments, which eventually result in sheet-like deposits (>3 mm). This evolution is observed to occur concurrently with the progression of plaque. These fragments and sheets of calcification can be easily identified by radiography as well as by computed tomography and intravascular imaging. Many imaging modalities have proposed spotty calcification to be a predictor of unstable plaque and have suggested more extensive calcification to be associated with stable plaques and perhaps the use of statin therapy. We will review the pathology of coronary calcification in humans with a focus on risk factors, relationship with plaque progression, correlation with plaque (in)stability, and effect of pharmacologic interventions. Copyright 2018 American College of Cardiology Foundation
    Keyword
    calcification
    imaging
    pathology
    stable plaque
    unstable plaque
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039962959&doi=10.1016%2fj.jcmg.2017.10.012&partnerID=40&md5=93967d0bda9dd9b12e4609af705bfb55; http://hdl.handle.net/10713/9182
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jcmg.2017.10.012
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