• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Hyper-radiosensitization Induced by the Histone Deacetylase Inhibitor Vorinostat, in glioblastoma

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Find Full text
    Author
    Diss, Eric
    Advisor
    Carrier, France
    Date
    2010
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Glioblastoma is an aggressive form of brain cancer that limits patients to an average survival of 12 months after diagnosis [9]. Long term survival is limited by an inability to completely eradicate glioblastomas even with high dose radiation. Glioblastoma's aggressiveness allows it to regenerate rapidly if even trace amounts of the cancerous cells are alive [9]. Even when combined with drugs such as temozolomide current standards of care call for partial brain radiation of 60 Gy [10]. Such high doses have detrimental effects on patients to include extreme nausea, skin damage, hair loss, general malaise, and links have been found to reduction in life expectancy [9]. In order to reduce these adverse effects, drugs that induce radiosensitization such as Vorinostat (SAHA), are key to furthering cancer research. By inducing a conformational change to a more open form in chromatin structure, HDAC inhibitors could sensitize cancer cells to radiation treatments that are harmful to the brain.
    Description
    University of Maryland in Baltimore. Molecular Medicine. M.S. 2010
    Keyword
    HDACI
    p53
    PTEN
    radiosensitivity
    vorinostat
    Glioblastoma
    Radiation-Sensitizing Agents
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/917
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Medicine

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.