Show simple item record

dc.contributor.authorSadacca, B.F.
dc.contributor.authorWied, H.M.
dc.contributor.authorLopatina, N.
dc.date.accessioned2019-05-17T13:21:14Z
dc.date.available2019-05-17T13:21:14Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045677434&doi=10.7554%2feLife.30373&partnerID=40&md5=14970ccf9e4252f46d7d00dc95ae4a5b
dc.identifier.urihttp://hdl.handle.net/10713/9166
dc.description.abstractUsing knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation of associative structure or cognitive maps. Here we tested between these accounts by recording OFC neurons in rats during an OFC-dependent sensory preconditioning task. We found that while OFC neurons were strongly driven by biological significance or reward predictions at the end of training, they also showed clear evidence of acquiring the incidental stimulus-stimulus pairings in the preconditioning phase, prior to reward training. These results support a role for OFC in representing associative structure, independent of value. Copyright 2018, eLife Sciences Publications Ltd. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the Intramural Research Program at the National Institute on Drug Abuse.en_US
dc.description.urihttps://dx.doi.org/10.7554/eLife.30373en_US
dc.language.isoen_USen_US
dc.publishereLife Sciences Publications Ltden_US
dc.relation.ispartofeLife
dc.subjectmodel-based reasoningen_US
dc.subject.meshNeuronsen_US
dc.subject.meshPrefrontal Cortexen_US
dc.subject.meshRatsen_US
dc.titleOrbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning tasken_US
dc.typeArticleen_US
dc.identifier.doi10.7554/eLife.30373
dc.identifier.pmid29513220


This item appears in the following Collection(s)

Show simple item record