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    Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task

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    Author
    Sadacca, B.F.
    Wied, H.M.
    Lopatina, N.
    Date
    2018
    Journal
    eLife
    Publisher
    eLife Sciences Publications Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.7554/eLife.30373
    Abstract
    Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation of associative structure or cognitive maps. Here we tested between these accounts by recording OFC neurons in rats during an OFC-dependent sensory preconditioning task. We found that while OFC neurons were strongly driven by biological significance or reward predictions at the end of training, they also showed clear evidence of acquiring the incidental stimulus-stimulus pairings in the preconditioning phase, prior to reward training. These results support a role for OFC in representing associative structure, independent of value. Copyright 2018, eLife Sciences Publications Ltd. All rights reserved.
    Sponsors
    This work was supported by the Intramural Research Program at the National Institute on Drug Abuse.
    Keyword
    model-based reasoning
    Neurons
    Prefrontal Cortex
    Rats
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045677434&doi=10.7554%2feLife.30373&partnerID=40&md5=14970ccf9e4252f46d7d00dc95ae4a5b; http://hdl.handle.net/10713/9166
    ae974a485f413a2113503eed53cd6c53
    10.7554/eLife.30373
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