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dc.contributor.authorGardner, M.P.H.
dc.contributor.authorConroy, J.C.
dc.contributor.authorStyer, C.V.
dc.date.accessioned2019-05-17T13:21:12Z
dc.date.available2019-05-17T13:21:12Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054353120&doi=10.7554%2feLife.38963&partnerID=40&md5=b37084d1a049296892cca953766d37be
dc.identifier.urihttp://hdl.handle.net/10713/9138
dc.description.abstractHow are decisions made between different goods? One theory spanning several fields of neuroscience proposes that their values are distilled to a single common neural currency, the calculation of which allows for rational decisions. The orbitofrontal cortex (OFC) is thought to play a critical role in this process, based on the presence of neural correlates of economic value in lateral OFC in monkeys and medial OFC in humans. We previously inactivated lateral OFC in rats without affecting economic choice behavior. Here we inactivated medial OFC in the same task, again without effect. Behavior in the same rats was disrupted by inactivation during progressive ratio responding previously shown to depend on medial OFC, demonstrating the efficacy of the inactivation. These results indicate that medial OFC is not necessary for economic choice, bolstering the proposal that classic economic choice is likely mediated by multiple, overlapping neural circuits. Copyright 2018, eLife Sciences Publications Ltd. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the Intramural Research Program at NIDA (GS).en_US
dc.description.urihttps://dx.doi.org/10.7554/eLife.38963en_US
dc.language.isoen_USen_US
dc.publishereLife Sciences Publications Ltden_US
dc.relation.ispartofeLife
dc.subjectmedial OFCen_US
dc.subject.meshDecision Makingen_US
dc.subject.meshPrefrontal Cortexen_US
dc.titleMedial orbitofrontal inactivation does not affect economic choiceen_US
dc.typeArticleen_US
dc.identifier.doi10.7554/eLife.38963
dc.identifier.pmid30281020


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