Medial orbitofrontal inactivation does not affect economic choice
Date
2018Journal
eLifePublisher
eLife Sciences Publications LtdType
Article
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How are decisions made between different goods? One theory spanning several fields of neuroscience proposes that their values are distilled to a single common neural currency, the calculation of which allows for rational decisions. The orbitofrontal cortex (OFC) is thought to play a critical role in this process, based on the presence of neural correlates of economic value in lateral OFC in monkeys and medial OFC in humans. We previously inactivated lateral OFC in rats without affecting economic choice behavior. Here we inactivated medial OFC in the same task, again without effect. Behavior in the same rats was disrupted by inactivation during progressive ratio responding previously shown to depend on medial OFC, demonstrating the efficacy of the inactivation. These results indicate that medial OFC is not necessary for economic choice, bolstering the proposal that classic economic choice is likely mediated by multiple, overlapping neural circuits. Copyright 2018, eLife Sciences Publications Ltd. All rights reserved.Sponsors
This work was supported by the Intramural Research Program at NIDA (GS).Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054353120&doi=10.7554%2feLife.38963&partnerID=40&md5=b37084d1a049296892cca953766d37be; http://hdl.handle.net/10713/9138ae974a485f413a2113503eed53cd6c53
10.7554/eLife.38963
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