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    Medial orbitofrontal inactivation does not affect economic choice

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    Author
    Gardner, M.P.H.
    Conroy, J.C.
    Styer, C.V.
    Date
    2018
    Journal
    eLife
    Publisher
    eLife Sciences Publications Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.7554/eLife.38963
    Abstract
    How are decisions made between different goods? One theory spanning several fields of neuroscience proposes that their values are distilled to a single common neural currency, the calculation of which allows for rational decisions. The orbitofrontal cortex (OFC) is thought to play a critical role in this process, based on the presence of neural correlates of economic value in lateral OFC in monkeys and medial OFC in humans. We previously inactivated lateral OFC in rats without affecting economic choice behavior. Here we inactivated medial OFC in the same task, again without effect. Behavior in the same rats was disrupted by inactivation during progressive ratio responding previously shown to depend on medial OFC, demonstrating the efficacy of the inactivation. These results indicate that medial OFC is not necessary for economic choice, bolstering the proposal that classic economic choice is likely mediated by multiple, overlapping neural circuits. Copyright 2018, eLife Sciences Publications Ltd. All rights reserved.
    Sponsors
    This work was supported by the Intramural Research Program at NIDA (GS).
    Keyword
    medial OFC
    Decision Making
    Prefrontal Cortex
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054353120&doi=10.7554%2feLife.38963&partnerID=40&md5=b37084d1a049296892cca953766d37be; http://hdl.handle.net/10713/9138
    ae974a485f413a2113503eed53cd6c53
    10.7554/eLife.38963
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    UMB Open Access Articles 2018

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