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dc.contributor.authorNathenson, M.J.
dc.contributor.authorBarysauskas, C.M.
dc.contributor.authorNathenson, R.A.
dc.date.accessioned2019-05-17T13:21:12Z
dc.date.available2019-05-17T13:21:12Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054770612&doi=10.1186%2fs12957-018-1505-4&partnerID=40&md5=16b2eb92f8b13c3121b4a481da24206e
dc.identifier.urihttp://hdl.handle.net/10713/9135
dc.description.abstractBackground: Retroperitoneal soft tissue sarcomas (STS) include a number of histologies but are rare, with approximately 3000 cases in the USA per year. Retroperitoneal STS have a high incidence of local and distant recurrence. The purpose of this study was to review the University of Maryland Medical Center's (UMMC) treatment experience of retroperitoneal STS, where the patient population served represents a diverse socioeconomic and ethnic catchment. Methods: IRB approval was obtained. We constructed a de-identified database of patients diagnosed with retroperitoneal liposarcomas (LPS) or leiomyosarcomas (LMS) treated at UMMC between 2000 and 2013. A total of 49 patients (Pts) with retroperitoneal STS met our eligibility criteria. Kaplan-Meier plots were used to graphically portray progression-free survival (PFS) and overall survival (OS). The log-rank test was used to compare time-to-event distributions. Results: The median OS for all patients (Pts) was 6.3 years, and the 2-year OS rate was 81%. The median PFS for all Pts was 1.8 years, and the 2-year PFS rate was 45%. There was no difference in OS and PFS among LMS and LPS patients; the median OS for LMS was 3.8 years vs. LPS 6.4 years (p = 0.33), and the median PFS for LMS was 1.2 years vs. LPS 2.5 years (p = 0.28). There was a significant difference between histology and race (p = 0.001). LPS were primarily Caucasian 86% vs. 14% black, whereas LMS were primarily black 52% vs. 33% Caucasian. OS was influenced by functional status, gender, American Joint Committee on Cancer (AJCC) stage, grade, histology, tumor size, and extent of resection. PFS was influenced by AJCC stage, grade, and extent of resection. Neither adjuvant chemotherapy (1 Pt) nor neoadjuvant/adjuvant radiation therapy (18 Pts) influenced OS or PFS. There was a non-significant difference that Pts who could undergo resection of local recurrence had improved 2-year OS, with 100% LMS and LPS compared to 2-year OS of 71% (LMS) and 78% (LPS) not undergoing resection of local recurrence. Conclusions: This study suggests a higher incidence of leiomyosarcoma in the African-American population. This study confirms the prognostic importance of grade, tumor size, AJCC stage, histology, and extent of resection in patient outcomes, at a large substantially diverse academic medical center. Future research into the biological features of liposarcoma and leiomyosarcoma Pts imparting these characteristics will be important to define. Copyright 2018 The Author(s).en_US
dc.description.urihttps://dx.doi.org/10.1186/s12957-018-1505-4en_US
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofWorld Journal of Surgical Oncology
dc.subjectLeiomyosarcomaen_US
dc.subjectLiposarcomaen_US
dc.subjectOverall survivalen_US
dc.subjectProgression-free survivalen_US
dc.subjectRetroperitonealen_US
dc.subjectSoft tissue sarcomaen_US
dc.titleSurgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcomaen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12957-018-1505-4
dc.identifier.pmid30309356


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