Neuroendocrine stress responses predict catecholamine-dependent working memory-related dorsolateral prefrontal cortex activity
JournalSocial Cognitive and Affective Neuroscience
PublisherOxford University Press
MetadataShow full item record
AbstractIt is generally thought that the effect of acute stress on higher-order functions such as working memory is, for an important part, mediated by central catecholamine activity. However, little is known about the association between neuroendocrine stress responses and catecholamine-dependent working memory-related brain function in the absence of stress. Here, we investigate for the first time in healthy humans (n=18) how neuroendocrine responses to stress (cortisol and alphaamylase) relate to fronto-parietal working memory activity changes in response to atomoxetine, a noradrenaline transporter inhibitor that selectively increases extracellular cortical dopamine and noradrenaline. We observed positive correlations between stress-induced cortisol (Pearson's r = 0.75, P < 0.001) and alpha amylase (r = 0.69, P = 0.02) increases and catecholamine-dependent working memory-related activity in dorsolateral prefrontal cortex. Stress-induced cortisol increases furthermore correlated with supramarginal gyrus working memory-related activity (r = 0.79, P < 0.001). Comparing high vs low stress responders revealed that these correlations were driven by decreased working memory activity on placebo and greater working memory activity increases following atomoxetine in high stress responders. These results further corroborate the notion that neuroendocrine responses to stress are an informative proxy of catecholamine function relevant to higher order functions and provide novel hints on the complex relationship between acute stress, catecholamine function and working memory. Copyright The Author (2017).
SponsorsDH's research is funded by a Kootstra post-doctoral fellowship and a Brains Unlimited pioneer grant (grant no: S.2015.1.02). TvA's research is funded by NIMH, and a ZonMW VIDI grant (grant no: 91712394). CW is funded by a Netherlands Organization for Scientific Research (NWO) Rubicon grant (grant no: 446-15-003, 2015).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85040632893&doi=10.1093%2fscan%2fnsx122&partnerID=40&md5=124d416b2b2097bca80190d5922f132a; http://hdl.handle.net/10713/9118
- Noradrenaline transporter blockade increases fronto-parietal functional connectivity relevant for working memory.
- Authors: Hernaus D, Casales Santa MM, Offermann JS, Van Amelsvoort T
- Issue date: 2017 Apr
- Pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation.
- Authors: Woodcock EA, Greenwald MK, Khatib D, Diwadkar VA, Stanley JA
- Issue date: 2019 Feb 1
- Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain.
- Authors: Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW
- Issue date: 2000 Mar 15
- Working memory load influences perceptual ambiguity by competing for fronto-parietal attentional resources.
- Authors: Intaitė M, Duarte JV, Castelo-Branco M
- Issue date: 2016 Nov 1
- Effects of treatment with the atypical neuroleptic quetiapine on working memory function: a functional MRI follow-up investigation.
- Authors: Meisenzahl EM, Scheuerecker J, Zipse M, Ufer S, Wiesmann M, Frodl T, Koutsouleris N, Zetzsche T, Schmitt G, Riedel M, Spellmann I, Dehning S, Linn J, Brückmann H, Möller HJ
- Issue date: 2006 Dec