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dc.contributor.authorKyritsi, F.
dc.contributor.authorLoffredo, C.A.
dc.contributor.authorZheng, Y.-L.
dc.date.accessioned2019-05-17T12:53:06Z
dc.date.available2019-05-17T12:53:06Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045072491&doi=10.1155%2f2018%2f3453808&partnerID=40&md5=0ac5c530c2cfcba441401dda4e419e3c
dc.identifier.urihttp://hdl.handle.net/10713/9117
dc.description.abstractWe investigated gender differences in the histopathologic presentation of bladder cancer cases in Egypt, where both urothelial cell carcinoma (UC) and squamous cell carcinoma (SCC) types are highly prevalent. We used logistic regression to estimate the unadjusted (OR) and adjusted odds ratio (AOR) and 95% confidence interval (CI) of the associations between gender and different histopathologic and sociodemographic parameters of 2,186 confirmed cases of primary bladder cancer (1,775 males and 411 females; 784 SCC and 1,402 UC). There were no statistically significant gender differences in tumor grade, stage, mucosal ulcer, or inflammatory cystitis, regardless of the cancer type, but men were less likely than women to have undergone cystectomy with pelvic lymphadenectomy. Having Schistosoma haematobium (SH) ova in the bladder tissue was significantly associated with male gender in the fully adjusted model of either SCC (AOR (95% CI) = 2.12 (1.15-3.89)) or UC cases (3.78 (1.89-7.55)). Compared to females, male cases were significantly older at time of diagnosis and smokers. In Egypt, regardless of the type of bladder cancer (SCC or UC), male more than female cases had evidence of SH infection, but not other histopathologic differences, in bladder tissue specimens. Copyright 2018 Fiorina Kyritsi et al.en_US
dc.description.sponsorshipThe authors thank Sameera Ezzat, Tamer El Hifnawy, and Doa’a Salah who supervised the recruitment of subjects for this study. Iman Gouda, Iman Loay, and Bhaskar Kallakury performed the expert pathology review of the cases. Data management services were provided by Nabiel N. Mikhail. This study was supported by a grant from the National Cancer Institute, National Institutes of Health (R01-CA115618 to Christopher A. Loffredo).en_US
dc.description.urihttps://dx.doi.org/10.1155/2018/3453808en_US
dc.language.isoen_USen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofAdvances in Urology
dc.subject.lcshBladder--Canceren_US
dc.subject.lcshHistology, Pathologicalen_US
dc.subject.lcshSex factors in diseaseen_US
dc.titleUrinary bladder cancer in Egypt: Are there gender differences in its histopathological presentation?en_US
dc.typeArticleen_US
dc.identifier.doi10.1155/2018/3453808


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