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dc.contributor.authorTao, Z.-Y.
dc.contributor.authorXue, Y.
dc.contributor.authorLi, J.-F.
dc.date.accessioned2019-05-17T12:53:06Z
dc.date.available2019-05-17T12:53:06Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059798318&doi=10.1155%2f2018%2f5406973&partnerID=40&md5=64e12257c8c909e52ae07d6b3447858d
dc.identifier.urihttp://hdl.handle.net/10713/9109
dc.description.abstractVisceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (miRNAs) play a significant role in visceral nociception through altering neurotransmitters, receptors and other genes at the posttranscriptional level. Under pathological conditions, one kind of miRNA may have several target mRNAs and several kinds of miRNAs may act on one target, suggesting complex interactions and mechanisms between miRNAs and target genes lead to pathological states. In this review we report on recent progress in examining miRNAs responsible for visceral sensitization and provide miRNA-based therapeutic targets for the management of visceral pain. Copyright 2018 Zhuo-Ying Tao et al.en_US
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (no. 81671097) and Shaanxi Province Natural Science Basic Research Foundation of China (no. 2016JM3015).en_US
dc.description.urihttps://dx.doi.org/10.1155/2018/5406973en_US
dc.language.isoen_USen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofBioMed Research International
dc.subject.meshVisceral Painen_US
dc.subject.meshMicroRNAsen_US
dc.titleDo MicroRNAs Modulate Visceral Pain?en_US
dc.typeArticleen_US
dc.identifier.doi10.1155/2018/5406973
dc.identifier.pmid30627562


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