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    Histologic comparison of direct pulp capping of rat molars with mta and different concentrations of simvastatin gel

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    Author
    Dianat, O.
    Mashhadiabbas, F.
    Ahangari, Z.
    Date
    2018
    Journal
    Journal of Oral Science
    Publisher
    Nihon University, School of Dentistry
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.2334/josnusd.16-0690
    Abstract
    Previous in vitro studies have suggested that simvastatin can be used as a direct pulp capping material due to its ability to induce odontoblastic differentiation and angiogenesis. The aim of this animal study was to evaluate the pulpal response to mineral trioxide aggregate (MTA) and four concentrations of simvastatin/MTA in combination. The study was conducted in two stages using four different simvastatin concentrations and MTA as a capping material for rat maxillary molars. The grades of inflammation and continuity of dentin formation were evaluated in hematoxylin and eosin (HE)-stained samples. Dentin thickness was determined by histomorphometric analysis, and the data were subjected to statistical analysis. On day 3, mild inflammation was observed in all groups. On day 7, the simvastatin groups showed a slightly higher rate of chronic inflammation. Inflammation was not present on day 30. Discontinuous dentin was present in all methylcellulose (control) samples. Continuous dentin was formed in all of the samples treated with 1.5% simvastatin. The greatest dentin thickness was observed after treatment with 1.5% simvastatin and MTA, followed by 0.5% simvastatin. Statistical analysis demonstrated no significant differences in dentin thickness and continuity between MTA and simvastatin at 0.5% and 1.5% (P > 0.05). Copyright 2018, Nihon University, School of Dentistry. All rights reserved.
    Keyword
    Direct pulp capping
    Histomorphometry
    MTA
    Rat molars
    Simvastatin
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044259647&doi=10.2334%2fjosnusd.16-0690&partnerID=40&md5=7550f269b99a3f36892cc532b06ed059; http://hdl.handle.net/10713/9107
    ae974a485f413a2113503eed53cd6c53
    10.2334/josnusd.16-0690
    Scopus Count
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    UMB Open Access Articles 2018

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