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dc.contributor.authorO'Brien, J.J.
dc.contributor.authorCooke, R.K.
dc.contributor.authorEbrahim-Nejad, A.A.
dc.date.accessioned2019-05-17T12:53:06Z
dc.date.available2019-05-17T12:53:06Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85042230577&doi=10.1093%2fAJCP%2fAQX109&partnerID=40&md5=322b69c435508f199d4ecc5335824030
dc.identifier.urihttp://hdl.handle.net/10713/9104
dc.description.abstractObjectives: Inconclusive RBC antibody identification (ABID) may delay RBC crossmatch. An increased number of inconclusive ABID was observed, and an algorithm was developed to improve ABID efficiency. Methods: RBC antibody screen (AS) and ABID were initially performed using solid-phase RBC adherence assay (SPRCA) and manual tube method. A retrospective analysis of AS and ABID results was performed pre- and postalgorithm implementation. Results: The number of inconclusive ABID results decreased from 26 to six per month pre- and postimplementation, respectively. SPRCA became the primary AS method, and manual tube became the gold standard for ABID. SPRCA was used for ABID upon reference specialist secondary review and allowed identification of 30 specific RBC antibodies, for which no patients developed signs or symptoms of a hemolytic transfusion reaction. Conclusions: RBC reference workflow using SPRCA and manual tube methods for AS and ABID decreases "inconclusive" ABID without adverse events. Copyright American Society for Clinical Pathology, 2017. All rights reserved.en_US
dc.description.urihttps://dx.doi.org/10.1093/AJCP/AQX109en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofAmerican Journal of Clinical Pathology
dc.subjectAntibody identificationen_US
dc.subjectInconclusive antibodyen_US
dc.subjectRed blood cellen_US
dc.subjectTransfusion medicineen_US
dc.titleAlgorithm to Manage Inconclusive RBC Antibodies by Reflex Manual Testingen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/AJCP/AQX109
dc.identifier.pmid29272886


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