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dc.contributor.authorAliyu, G.
dc.contributor.authorEl-Kamary, S.S.
dc.contributor.authorAbimiku, A.
dc.date.accessioned2019-05-17T12:53:05Z
dc.date.available2019-05-17T12:53:05Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053257059&doi=10.1371%2fjournal.pone.0191387&partnerID=40&md5=735588454f39753e232a0b19a271b88c
dc.identifier.urihttp://hdl.handle.net/10713/9098
dc.description.abstractBackground Convergence of tuberculosis (TB) and HIV epidemics is associated with higher morbidity and mortality risks and understanding their distribution across key demographic factors is essential for prevention and control. This analysis examines the prevalence of TB, HIV and TB-HIV coinfection across age and gender in patients with presumptive TB seeking care at the National TB and Leprosy Training Center in Nigeria. Methods Samples from 1603 presumptive pulmonary TB cases who provided informed consent were evaluated with a sequential testing algorithm that included a smear microscopy, cultures in liquid and broth media and then genotyping by Hain line probe assays. HIV was serially tested with two HIV rapid assays and retested with a third assay in non-conclusive samples. Results Twenty-three percent (375/1603) had confirmed pulmonary TB infection, 23.6% (378/1603) were positive for HIV infection and 26.9% (101/375) of the confirmed TB cases were HIV coinfected. Males had a higher prevalence of TB: 27.6% vs. 18.0%, p < .0001; and a lower prevalence of HIV: 19.0% vs. 29.6%, p < .0001. In the age range of 25-29 years, males were twice as likely to have TB (OR = 2.2; 95% confidence interval [CI]: 1.3-3.9, p = 0.0032) while females were five times more likely to have HIV (OR = 4.8; 95% CI: 2.6-8.9, p < .0001). Persons with TB-HIV coinfection were more likely to be young, female and less likely to be married. Conclusion Younger females with a high burden of HIV may be under-diagnosed and under-reported for TB in Nigeria. Community programs for intensified and early detection of TB and HIV targeting younger females are needed in this setting. Copyright 2018 Aliyu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.description.urihttps://dx.doi.org/10.1371/journal.pone.0191387en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONE
dc.subject.meshDemographyen_US
dc.subject.meshTuberculosisen_US
dc.subject.meshHIVen_US
dc.subject.meshEpidemicsen_US
dc.subject.meshAfrica South of the Saharaen_US
dc.titleDemography and the dual epidemics of tuberculosis and HIV: Analysis of cross-sectional data from Sub-Saharan Africaen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0191387
dc.identifier.pmid30192746


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