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    A Food-Derived Dietary Supplement Containing a Low Dose of Iron Improved Markers of Iron Status Among Nonanemic Iron-Deficient Women

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    Author
    D'Adamo, C.R.
    Novick, J.S.
    Feinberg, T.M.
    Date
    2018
    Journal
    Journal of the American College of Nutrition
    Publisher
    Routledge
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1080/07315724.2018.1427158
    Abstract
    Objective: Iron deficiency is the most common nutrient deficiency in the world. While deficiency can often be resolved through dietary supplementation with iron, adverse events are common and frequently preclude compliance. The objective of this study was to determine whether a food-derived dietary supplement containing a low dose of iron and nutrients that increase iron absorption could resolve iron deficiency with fewer adverse events than reported at higher doses. Methods: A pilot clinical trial (NCT02683369) was conducted among premenopausal women with nonanemic iron deficiency that was verified by blood screening. Participants consumed a dietary supplement (Blood Builder®/Iron Response®) once daily for 8 weeks containing 26 mg of iron, vitamin C, folate, and other food-derived nutrients. Primary outcomes were markers of iron status (serum ferritin, hemoglobin, soluble transferrin receptor, total body iron stores) and secondary outcomes were self-reported fatigue and energy. All outcomes were assessed at baseline and 8 weeks. Adverse events were monitored with questionnaires, daily diaries, and contact with a physician. Dependent samples t test and Wilcoxon signed-rank test were used to analyze outcomes. Results: Twenty-three participants enrolled in the study. Iron deficiency was resolved in the sample (mean serum ferritin: baseline = 13.9 μg/L, 8 weeks = 21.1 μg/L, p < 0.001). All other markers of iron status, fatigue, and energy also improved during the study (p < 0.04). No adverse events were reported. Conclusions: While larger and controlled studies are needed to confirm these findings, a food-derived dietary supplement with a low dose of iron and absorption-enhancing nutrients resolved iron deficiency and improved all other markers of iron status without any adverse events. Copyright 2018 Christopher R. D'Adamo, James S. Novick, Termeh M. Feinberg, Valerie J. Dawson, and Larry E. Miller Copyright 2018, Copyright Christopher R. D'Adamo, James S. Novick, Termeh M. Feinberg, Valerie J. Dawson, and Larry E. Miller.
    Sponsors
    Support for this research was provided by FoodState, Inc. and the National Institute of Diabetes and Digestive and Kidney Diseases grant number T35 DK095737.
    Keyword
    dietary supplement
    ferritin
    folate
    hemoglobin
    Iron
    nonanemic iron deficiency
    soluble transferrin receptor
    total body iron stores
    vitamin C
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043707706&doi=10.1080%2f07315724.2018.1427158&partnerID=40&md5=2148a697f83187f8a53568878c500a97; http://hdl.handle.net/10713/9079
    ae974a485f413a2113503eed53cd6c53
    10.1080/07315724.2018.1427158
    Scopus Count
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    UMB Open Access Articles 2018

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