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    Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats

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    Author
    Da Silva, Joyce T.
    Zhang, Y.
    Asgar, J.
    Date
    2018
    Journal
    Behavioural Brain Research
    Publisher
    Elsevier B.V.
    Type
    Article
    
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    See at
    https://dx.doi.org/10.1016/j.bbr.2018.04.055
    Abstract
    Diffuse noxious inhibitory control (DNIC), which involves endogenous pain modulation, has been investigated as a potential mechanism for the differences in pain modulation observed between men and women, though the literature shows contradictory findings. We used a capsaicin-induced DNIC behavioral assay and resting state functional magnetic resonance imaging (rsfMRI) to assess the effect of testosterone on pain modulation and related brain circuitry in rats. We hypothesized that testosterone is required for DNIC that leads to efficient pain inhibition by increasing descending pain modulation. Male, female, and orchidectomized (GDX) male rats had a capsaicin injection into the forepaw to induce DNIC and mechanical thresholds were observed on the hindpaw. rsfMRI scans were acquired before and after capsaicin injection to analyze the effects of DNIC on periaqueductal gray (PAG), anterior cingulate cortex (ACC) and nucleus accumbens (NAc) connectivity to the whole brain. The strength of DNIC was higher in males compared to females and GDX males. PAG connectivity with prelimbic cortex (PrL), ACC and insula was stronger in males compared to females and GDX males, whereas females and GDX males had increased connectivity between the right ACC, hippocampus and thalamus. GDX males also showed a stronger connectivity between right ACC and NAc, and right NAc with PrL, ACC, insula and thalamus. Our findings suggest that testosterone plays a key role in reinforcing the endogenous pain inhibitory system, while circuitries related to reward and emotion are more strongly recruited in the absence of testosterone. Copyright 2018 The Authors
    Sponsors
    This study was supported by NIH-NIDCR grant DE019448 (JYR) . The authors have no conflicts of interest to declare.
    Keyword
    Anterior cingulate cortex
    Brain networks
    Diffuse noxious inhibitory control
    Nucleus accumbens
    Periaqueductal gray
    Testosterone
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046765383&doi=10.1016%2fj.bbr.2018.04.055&partnerID=40&md5=2c656454e8035ee45fdfc83f7e1ffd2f; http://hdl.handle.net/10713/9061
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbr.2018.04.055
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    UMB Open Access Articles 2018

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