Show simple item record

dc.contributor.authorJiang, M.
dc.contributor.authorGao, Z.
dc.contributor.authorWang, J.
dc.date.accessioned2019-05-17T12:53:01Z
dc.date.available2019-05-17T12:53:01Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85039058033&doi=10.1002%2f1873-3468.12937&partnerID=40&md5=3006dbe607923e31fc077f063b9cfd77
dc.identifier.urihttp://hdl.handle.net/10713/9040
dc.description.abstractTo analyze transcription factors involved in gene regulation by testis-specific TAF (tTAF), tTAF-dependent promoters were mapped and analyzed in silico. Core promoters show decreased AT content, paucity of classical promoter motifs, and enrichment with translation control element CAAAATTY. Scanning of putative regulatory regions for known position frequency matrices identified 19 transcription regulators possibly contributing to tTAF-driven gene expression. Decreased male fertility associated with mutation in one of the regulators, Acj6, indicates its involvement in male reproduction. Transcriptome study of testes from male mutants for tTAF, Acj6, and previously characterized tTAF-interacting factor Modulo implies the existence of a regulatory hierarchy of tTAF, Modulo and Acj6, in which Modulo and/or Acj6 regulate one-third of tTAF-dependent genes. Copyright 2017 Federation of European Biochemical Societiesen_US
dc.description.sponsorshipThis work was supported by NIH research grant GM061549 to DIN, National Natural Science Foundation of China 31701282 to MJ, National Natural Science Foundation of China 31702329 to JW, and National Natural Science Foundation of China 31371497 to ZG.en_US
dc.description.urihttps://dx.doi.org/10.1002/1873-3468.12937en_US
dc.language.isoen_USen_US
dc.publisherWiley Blackwellen_US
dc.relation.ispartofFEBS Letters
dc.subjectDrosophilaen_US
dc.subjectgene-specific transcription regulatoren_US
dc.subjecthierarchical transcriptional circuiten_US
dc.subjectspermatogenesisen_US
dc.subjecttestis-specific TAFen_US
dc.titleEvidence for a hierarchical transcriptional circuit in Drosophila male germline involving testis-specific TAF and two gene-specific transcription factors, Mod and Acj6en_US
dc.typeArticleen_US
dc.identifier.doi10.1002/1873-3468.12937
dc.identifier.pmid29235675


This item appears in the following Collection(s)

Show simple item record