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    Contrast mechanisms for tumor cells by high-frequency ultrasound

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    Author
    Juntarapaso, Y.
    Miyasaka, C.
    Tutwiler, R.L.
    Date
    2018
    Journal
    Open Neuroimaging Journal
    Publisher
    Bentham Science Publishers B.V.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.2174/1874440001812010105
    Abstract
    Scanning Acoustic Microscopy (SAM) is a powerful technique for both the non-destructive determination of mechanical and elastic properties of biological specimens and for the ultrasonic imaging at a micrometer resolution. The implication of biomechanical properties during the onset and progression of disease has been established rendering a profound understanding of the relationship between mechanoelastic and biochemical signaling at a molecular level crucial. Computer simulation algorithms were developed for the generation of images and the investigation of contrast mechanisms in high-frequency and ultra-high frequency SAM. Furthermore, we determined the mechanical and elastic properties of HeLa and MCF-7 cells. Algorithms for simulating V(z) responses were developed based on the ray and wave theory (angular spectrum). Theoretical simulations for high-frequency SAM array designs were performed with the Field II software. In these simulations, we applied phased array beam formation and dynamic apodization and focusing. The purpose of our transducer simulations was to explore volumetric imaging capabilities. The novel transducer arrays designed in this research aim at improving the performance of SAM systems by introducing electronic steering and hence, allowing for the 4D imaging of cells and tissues. Copyright 2018 Juntarapaso et al.
    Keyword
    Biomechanical properties
    Cancer metastasis
    Dynamic apodization
    Focused ultrasound
    High-frequency ultrasound
    Phased arrays
    Scanning acoustic microscopy
    Tumor microenvironment
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062062057&doi=10.2174%2f1874440001812010105&partnerID=40&md5=f7cdef1d7399c5ed74e67a897b877a26; http://hdl.handle.net/10713/9033
    ae974a485f413a2113503eed53cd6c53
    10.2174/1874440001812010105
    Scopus Count
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