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dc.contributor.authorWhittaker, C.F.
dc.contributor.authorMiklich, M.A.
dc.contributor.authorPatel, R.S.
dc.date.accessioned2019-05-17T12:52:59Z
dc.date.available2019-05-17T12:52:59Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054559361&doi=10.2215%2fCJN.00580118&partnerID=40&md5=3f68e81bdf1a837c0e95d89cc90f18ad
dc.identifier.urihttp://hdl.handle.net/10713/9026
dc.description.abstractEnsuring patient safety is a priority of medical care because iatrogenic injury has been a primary concern. Medications are an important source ofmedical errors, and kidney disease is a thoroughfare of factors threatening safe administration of medicines. Principal among these is reduced kidney function because almost half of all medications used are eliminated via the kidney. Additionally, kidney patients often suffer from multimorbidity, including diabetes, hypertension, and heart failure, with a range of prescribers who often do not coordinate treatments. Patients with kidney disease are also susceptible to further kidney injury andmetabolic derangements from medications, which can worsen the disease. In this review, we will present the key issues and threats to safe medication use in kidney disease, with a focus on predialysis CKD, as the scope of medication safety in ESKD and transplantation are unique and deserve their own consideration. We discuss drugs that need to be avoided or dose modified, and reviewthe complications of a range ofmedications routinely administered in CKD, as these also call for cautious use. Copyright 2018 by the American Society of Nephrology.en_US
dc.description.sponsorshipThis work was supported by Baltimore Veterans Affairs Patient Safety Center of Inquiry which is funded by the Veterans Affairs National Patient Center for Patient Safety in White River Junction, Vermont.en_US
dc.description.urihttps://dx.doi.org/10.2215/CJN.00580118en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Nephrologyen_US
dc.relation.ispartofClinical Journal of the American Society of Nephrology
dc.subjectRenal Insufficiency, Chronicen_US
dc.subjectrenal impairmenten_US
dc.subjectkidney diseaseen_US
dc.subjectdrug safetyen_US
dc.titleMedication safety principles and practice in CKDen_US
dc.typeReviewen_US
dc.identifier.doi10.2215/CJN.00580118
dc.identifier.pmid29915131


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