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dc.contributor.authorElnabawi, Omar
dc.date.accessioned2019-05-08T17:06:18Z
dc.date.available2019-05-08T17:06:18Z
dc.identifier.urihttp://hdl.handle.net/10713/9007
dc.description2018
dc.descriptionBiomedical Sciences-Dental School
dc.descriptionUniversity of Maryland at Baltimore
dc.descriptionM.S.
dc.description.abstractObjective: To determine the effects of selectively ablating transient receptor potential vanilloid 1 (TRPV1)-expressing nociceptors on orthodontic tooth movement, pain, and alveolar bone remodeling. Methods: Resiniferatoxin (RTX) or vehicle was stereotaxically injected into left trigeminal ganglia in adult C57BL/6 mice. After 1 week, orthodontic spring was placed between left maxillary first molar and upper incisors. Pain level was evaluated by measuring mouse grimace scale (MGS) and bite force before and after 1, 3, and 7 days following the procedures. After 12 days, micro-CT was used to quantify tooth movement and analyzing alveolar bone changes. Results: Experimental tooth movement increased MGS scores and decreased bite force. RTX ablation of TRPV1+ nociceptors attenuated MGS scores and relieved the reduction in bite force. The extent of tooth movement was decreased in RTX-treated group, but interradicular alveolar bone volume was not affected. Conclusion: Selective ablation of TRPV1+ nociceptors significantly decreases tooth movement and pain.
dc.subjectDentistry
dc.subjectNeurosciences
dc.subjectCellular biology
dc.subjectAlveolar Bone, Bone Remodeling, Orthodontics, Pain, TRPV1
dc.titleThe Role of Nociceptors in Orthodontic Tooth Movement, Pain, and Alveolar Bone Remodeling
dc.typedissertationen_US
dc.date.updated2019-04-30T11:36:20Z
dc.language.rfc3066en
dc.contributor.advisorPae, Eung-Kwon
refterms.dateFOA2019-05-08T17:06:19Z


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